School of Medicine, Foshan University, Foshan, 528000, People's Republic of China.
Drug Des Devel Ther. 2024 Oct 2;18:4413-4426. doi: 10.2147/DDDT.S477381. eCollection 2024.
Herbal pairs are unique combinations of two relatively fixed herbs that are used in clinical practice. This is the most fundamental and straightforward form of multiple herbal treatment that aims to attain specific efficacy through unique methods. Coptidis Rhizoma ("Huanglian" in Chinese) and Magnoliae Officinalis Cortex ("Houpo" in Chinese) which are commonly used in combination and could also be used as important components of other prescriptions to treat damp-heat dysentery, splenic and stomach disorders, and qi stagnation in clinical practice. However, there is currently no summary on the compatibility of Huanglian and Houpo about traditional use, phytochemistry, and pharmacological activity. It was found the combination or separate extraction of the two drugs may affect the main active components, and new components may be produced after the combined extraction. At the same time, Huanglian and Houpo herb pair exhibited antiviral, anti-inflammatory, antibacterial and other pharmacological effects. At present, research mainly focuses on the indicator components of Huanglian and Houpo, such as berberine, magnolol, and magnolol. The models used for pharmacological validation are limited, mainly including ulcerative colitis, pneumonia, bacterial infections, etc. In order to verify the pharmacological activity of the combination of Huanglian and Houpo, it is necessary to try more in vitro and in vivo models. It's still need to study the compatibility mechanism of the Huanglian and Houpo drug pair, including but not limited to the interactions between different components and the impact of compatibility on efficacy, bioequivalence studies, and the impact of different dosage forms on pharmacokinetics in the future. It's believed that the systematic review provided comprehensive information for the study of Huanglian-Houpo drug pair, which will help highlight the importance of the Huanglian-Houpo herb pair and provide some clues for future research on this herb pair.
草药对药是指临床使用的两种相对固定的草药的独特组合。这是多种草药治疗中最基本和直接的形式，旨在通过独特的方法达到特定的疗效。黄连和厚朴在临床上常被组合使用，也可作为其他方剂的重要组成部分，用于治疗湿热痢疾、脾胃不和、气滞等病症。然而，目前关于黄连和厚朴的传统应用、植物化学和药理活性的综合信息尚未报道。研究发现，两药合用或分别提取可能会影响主要活性成分，联合提取后可能会产生新的成分。同时，黄连和厚朴药对表现出抗病毒、抗炎、抗菌等药理作用。目前，研究主要集中在黄连和厚朴的指标成分，如小檗碱、厚朴酚、和和厚朴酚等。药理验证的模型有限，主要包括溃疡性结肠炎、肺炎、细菌感染等。为了验证黄连和厚朴组合的药理活性，有必要尝试更多的体外和体内模型。仍需研究黄连和厚朴药对的配伍机制，包括但不限于不同成分之间的相互作用以及配伍对疗效的影响、生物等效性研究以及不同剂型对药代动力学的影响等。相信本综述为黄连-厚朴药对的研究提供了全面的信息，有助于突出黄连-厚朴药对的重要性，并为今后对该药对的研究提供一些线索。
