Zhang Yintao, Jiang Wanghao, Li Teng, Xu Hangwei, Zhu Yimiao, Fang Kerui, Ren Xinyu, Wang Shanshan, Chen Yuzong, Zhou Ying, Zhu Feng
College of Pharmaceutical Sciences, Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China.
Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China.
Nucleic Acids Res. 2025 Jan 6;53(D1):D738-D747. doi: 10.1093/nar/gkae863.
The subcellular compartment-specific molecular interactions (SCSIs) are the building blocks for most molecular functions, biological processes and disease pathogeneses. Extensive experiments have therefore been conducted to accumulate the valuable information of SCSIs, but none of the available databases has been constructed to describe those data. In this study, a novel knowledge base SubCELL is thus introduced to depict the landscape of SCSIs among DNAs/RNAs/proteins. This database is UNIQUE in (a) providing, for the first time, the experimentally-identified SCSIs, (b) systematically illustrating a large number of SCSIs inferred based on well-established method and (c) collecting experimentally-determined subcellular locations for the DNAs/RNAs/proteins of diverse species. Given the essential physiological/pathological role of SCSIs, the SubCELL is highly expected to have great implications for modern molecular biological study, which can be freely accessed with no login requirement at: https://idrblab.org/subcell/.
亚细胞区室特异性分子相互作用（SCSIs）是大多数分子功能、生物过程和疾病发病机制的构建模块。因此，人们进行了大量实验以积累SCSIs的宝贵信息，但尚未构建任何可用数据库来描述这些数据。在本研究中，因此引入了一个新的知识库SubCELL来描绘DNA/RNA/蛋白质之间的SCSIs全景。该数据库的独特之处在于：（a）首次提供实验确定的SCSIs；（b）系统地阐明基于成熟方法推断出的大量SCSIs；（c）收集不同物种DNA/RNA/蛋白质的实验确定的亚细胞定位。鉴于SCSIs至关重要的生理/病理作用，SubCELL有望对现代分子生物学研究产生重大影响，可通过以下网址免费访问，无需登录：https://idrblab.org/subcell/ 。
