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波兰产 OXA-244 的大肠杆菌的几种流行和多种散发性基因型;ST38 克隆占主导地位。

Several epidemic and multiple sporadic genotypes of OXA-244-producing Escherichia coli in Poland; predominance of the ST38 clone.

机构信息

Department of Molecular Microbiology, National Medicines Institute, Chełmska 30/34, Warsaw, 00-725, Poland.

Department of Epidemiology and Clinical Microbiology, National Reference Centre for Susceptibility Testing, National Medicines Institute, Chełmska 30/34, Warsaw, 00-725, Poland.

出版信息

Eur J Clin Microbiol Infect Dis. 2024 Dec;43(12):2465-2472. doi: 10.1007/s10096-024-04954-0. Epub 2024 Oct 7.

DOI:10.1007/s10096-024-04954-0
PMID:39373812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11608361/
Abstract

OXA-244-producing Escherichia coli (OXA-244-Ec) has disseminated in Europe, mostly in the community. In Poland it has spread since 2017, especially in 2023, but in contrast to other countries, all isolates have been identified in hospitals so far. The isolates (n = 101) represented one large and two limited outbreaks in different regions, and multiple epidemiologically and genetically non-related organisms. The OXA-244-Ec population consisted of 14 STs, with ST38 dominating. The ST38 isolates belonged to two major lineages, Clusters A and B, responsible for two of the hospital outbreaks. Enhanced concern and vigilance are necessary in the OXA-244-Ec surveillance.

摘要

产 OXA-244 大肠埃希菌(OXA-244-Ec)已在欧洲传播,主要在社区中。在波兰,它自 2017 年以来一直在传播,尤其是在 2023 年,但与其他国家不同的是,迄今为止所有分离株均在医院中发现。这些分离株(n=101)代表了不同地区的一次大规模和两次有限爆发,以及多个在流行病学和遗传学上没有关联的生物体。OXA-244-Ec 种群由 14 个 ST 组成,其中 ST38 占主导地位。ST38 分离株属于两个主要谱系,A 群和 B 群,这两个谱系与两个医院爆发有关。因此,需要对 OXA-244-Ec 进行监测,并增强关注和警惕。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2f/11608361/aa7c9ccfc305/10096_2024_4954_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2f/11608361/85e143bc01fd/10096_2024_4954_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2f/11608361/aa7c9ccfc305/10096_2024_4954_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2f/11608361/85e143bc01fd/10096_2024_4954_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b2f/11608361/aa7c9ccfc305/10096_2024_4954_Fig2_HTML.jpg

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