从海洋来源真菌青霉属菌株HN-66中分离得到的三种新型抗菌麦考酚酸衍生物
Three New Antibacterial Mycophenolic Acid Derivatives from the Marine-Derived Fungus Penicillium sp. HN-66.
作者信息
Mo TuXiang, Qin YuYue, Zhang Yue, Liang YongBin, Li XiaoBao, Li WanShan, Chen GuangYing
机构信息
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, 571158, China.
出版信息
Chem Biodivers. 2025 Jan;22(1):e202401657. doi: 10.1002/cbdv.202401657. Epub 2024 Nov 7.
Three new mycophenolic acid derivatives, penicacids L-N (1-3), together with four known analogues, were isolated from a fungus Penicillium sp. HN-66 derived from a South China Sea marine sediment. The structures of compounds 1-3 were determined on the basis of HR-ESI-MS, NMR (H, C, HSQC and HMBC) data analyses, and comparison of optical rotations. Antimicrobial activities of 1-7 were tested. The results showed that compounds 1-3 and 5-7 had weak inhibitory effects against E. coli ATCC 25922 with the MIC values of 50 μg/mL.
从一株源自中国南海海洋沉积物的青霉菌 Penicillium sp. HN-66 中分离得到了三种新的霉酚酸衍生物，即青霉酸 L-N（1-3），以及四种已知类似物。通过高分辨电喷雾电离质谱（HR-ESI-MS）、核磁共振（H、C、HSQC 和 HMBC）数据分析以及旋光度比较确定了化合物 1-3 的结构。测试了 1-7 的抗菌活性。结果表明，化合物 1-3 和 5-7 对大肠杆菌 ATCC 25922 具有较弱的抑制作用，最低抑菌浓度（MIC）值为 50 μg/mL。
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