Yang Di, Zhang Jing, Cui Xiaoli, Ma Jian, Wang Chunyan, Piao Haozhe
Department of Gynecology, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Shenyang, China.
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Microbiol. 2022 Sep 15;13:985561. doi: 10.3389/fmicb.2022.985561. eCollection 2022.
The different human papillomavirus (HPV) strains cause warts in various regions of the body. However, considering that the status and genotype distribution of HPV infection in women in Shenyang remain unknown, herein, we investigated the epidemiological characteristics of high-risk HPV (HR-HPV) infection in women in Shenyang, as well as the current state of HPV infection in Shenyang, to provide a theoretical basis for the prevention and treatment of cervical cancer. From December 2018 to December 2021, 6,432 urban and rural women from the Liaoning Cancer Hospital and the Sujiatun Women and Infants' Hospital were assessed via the Thinprep cytology test (TCT) and HR-HPV detection. Of the 5,961 women enrolled, 739 were HPV positive (12.40%) and 562 were TCT positive (9.43%). Statistical analyses identified the following HPV risk factors: high school education or lower [OR = 1.426 (1.199-1.696), < 0.001], age at first sexual encounter ≤ 19 years [OR = 1.496 (1.008-2.220), = 0.046], and number of sexual partners > 1 [OR = 1.382 (1.081-1.768), = 0.010], atypical squamous cells of undetermined significance (ASCUS) and above [OR = 10.788 (8.912-13.060), < 0.001], non-condom-based contraception [OR = 1.437 (1.103-1.871), = 0.007], nationalities other than Han [OR = 1.690 (1.187-2.406), = 0.004], rural residence [OR = 1.210 (1.031-1.419), = 0.020]. Compared to the HPV infection rate of women aged 56-65, that in women aged 35-45 [OR = 0.687 (0.549-0.860), = 0.001] and 46-55 [OR = 0.740 (0.622-0.879), = 0.001] decreased significantly. To conclude, risk factors of HPV infection among female patients include high school age and below, initial sexual encounter at age ≤ 19 years, number of sexual partners > 1, ASCUS and above, non-condom contraception, nationalities other than Han nationality and rural population. Collectively, this study provides insights for the improved prevention and treatment of cervical cancer.
不同的人乳头瘤病毒（HPV）毒株会导致身体不同部位出现疣。然而，鉴于沈阳女性HPV感染的状况和基因型分布尚不清楚，在此我们调查了沈阳女性高危型HPV（HR-HPV）感染的流行病学特征以及沈阳HPV感染的现状，为宫颈癌的防治提供理论依据。2018年12月至2021年12月，对来自辽宁省肿瘤医院和苏家屯区妇幼保健院的6432名城乡女性进行了薄层液基细胞学检测（TCT）和HR-HPV检测。在纳入的5961名女性中，739名HPV呈阳性（12.40%），562名TCT呈阳性（9.43%）。统计分析确定了以下HPV危险因素：高中及以下学历[比值比（OR）=1.426（1.199-1.696），P<0.001]、首次性行为年龄≤19岁[OR =1.496（1.008-2.220），P =0.046]、性伴侣数量>1[OR =1.382（1.081-1.768），P =0.010]、意义不明确的非典型鳞状细胞（ASCUS）及以上[OR =10.788（8.912-13.060），P<0.001]、非避孕套避孕[OR =1.437（1.103-1.871），P =0.007]、非汉族[OR =1.690（1.187-2.406），P =0.004]、农村居民[OR =1.210（1.031-1.419），P =0.020]。与56-65岁女性的HPV感染率相比，35-45岁[OR =0.687（0.549-0.860），P =0.001]和46-55岁[OR =0.740（0.622-0.879），P =0.001]女性的感染率显著降低。总之，女性患者HPV感染的危险因素包括高中及以下学历、首次性行为年龄≤19岁、性伴侣数量>1、ASCUS及以上、非避孕套避孕、非汉族以及农村人口。总体而言，本研究为改进宫颈癌的防治提供了见解。
