Rao Chandana N, Jyotsna C S, Somaya K Zana, Gupta Swati, Bhat Mayur
Department of Audiology and Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, 576104 India.
Indian J Otolaryngol Head Neck Surg. 2024 Oct;76(5):4757-4759. doi: 10.1007/s12070-024-04830-5. Epub 2024 Jun 25.
A notch is defined as the frequency point at which hearing loss is greater than 15 dB when compared to one octave above and below. C3 dip or 1 kHz notch is rarely seen and not much information is known about the clinical profile of such condition. The aim of this case report is to highlight the audiological profile of a case with 1kHz notch and discuss the possible causes for the same. Case A (16 yrs) was referred with a complaint of hearing loss and speech understanding difficulty specially at school. The teen had taken multiple medications for several health related issues like malaria, appendicitis and the understanding difficulty was evident during this period. Detailed audiological evaluation revealed a significant C3 dip in the right ear and normal hearing sensitivity in the left ear. Evidences from literature suggests strong correlation between drugs like Cefotetan, cefotaime, piperacillin, ampicillin (appendicitis treatment) and chloroquine (malaria) and hearing loss. Hence, we concluded that the possible cause of 1khz is ototoxic medication.
切迹被定义为与上下一个倍频程相比，听力损失大于15分贝的频率点。C3下降或1千赫切迹很少见，关于这种情况的临床特征了解不多。本病例报告的目的是突出1千赫切迹病例的听力学特征，并讨论其可能原因。病例A（16岁）因听力损失和言语理解困难前来就诊，特别是在学校时。该青少年因疟疾、阑尾炎等多种与健康相关的问题服用了多种药物，在此期间言语理解困难明显。详细的听力学评估显示右耳有明显的C3下降，左耳听力敏感度正常。文献证据表明，头孢替坦、头孢噻肟、哌拉西林、氨苄西林（阑尾炎治疗药物）和氯喹（疟疾治疗药物）等药物与听力损失之间有很强的相关性。因此，我们得出结论，1千赫切迹的可能原因是耳毒性药物。
