Letukienė Austėja, Hendrixson Vaiva, Ginevičienė Valentina
Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Front Med (Lausanne). 2024 Sep 23;11:1421962. doi: 10.3389/fmed.2024.1421962. eCollection 2024.
The relationship between exercise and obesity has attracted increasing attention from researchers worldwide in recent years. The aim of the present study was to analyze the current knowledge and scientific trends of research into myokines and exercise in the context of obesity and provide ideas for future research strategies to prevent obesity. The study conducted a comprehensive bibliometric analysis of 300 scientific publications related to myokines, exercise, and obesity from 2004 to 2024. Applying the VOSviewer tool, the analysis revealed a significant increase over time in the number of publications on these topics, with a total of 1,142 related keywords identified. Key themes identified in the analysis included molecular processes, new organokines, skeletal muscle research, model organism studies, and human studies based on sex and age differences. The study highlighted the growing interest in the molecular mechanisms of obesity and role of myokines. Results showed a substantial increase in publications from 2014 to 2024, with a focus on new organokines (myokines, adipokines) and animal models. The analysis underscored the importance of myokines in modulating metabolic processes and their potential therapeutic implications in managing non-communicable diseases such as obesity. Furthermore, the study revealed the close relationship between exercise, myokine production, and regulation of metabolism, stress response, and inflammation. In conclusion, over the last years, increasing research interest has been focused on the molecular mechanisms of obesity and benefits of exercise, and probably will be focused on a set of myokines released during muscle contraction. A newly identified myokines has emerged as a promising marker for the prevention and control of obesity.
近年来，运动与肥胖之间的关系已引起全球研究人员越来越多的关注。本研究的目的是在肥胖背景下分析有关肌动蛋白和运动的现有知识及科学研究趋势，并为预防肥胖的未来研究策略提供思路。该研究对2004年至2024年期间与肌动蛋白、运动和肥胖相关的300篇科学出版物进行了全面的文献计量分析。应用VOSviewer工具进行分析，结果显示这些主题的出版物数量随时间显著增加，共识别出1142个相关关键词。分析确定的关键主题包括分子过程、新的器官因子、骨骼肌研究、模式生物研究以及基于性别和年龄差异的人体研究。该研究突出了对肥胖分子机制和肌动蛋白作用的兴趣日益增加。结果表明，2014年至2024年期间出版物大幅增加，重点是新的器官因子（肌动蛋白、脂肪因子）和动物模型。分析强调了肌动蛋白在调节代谢过程中的重要性及其在管理肥胖等非传染性疾病方面的潜在治疗意义。此外，该研究揭示了运动、肌动蛋白产生与代谢、应激反应和炎症调节之间的密切关系。总之，在过去几年中，越来越多的研究兴趣集中在肥胖的分子机制和运动的益处上，并且可能会集中在肌肉收缩过程中释放的一组肌动蛋白上。一种新发现的肌动蛋白已成为预防和控制肥胖的有希望的标志物。
