Tran Pierre, Rama Sai P, Prasad Chaya, Do Hanh, Parsa Cyrus
Department of Pathology, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E. 2nd St., Pomona, CA 91766, United States.
Master of Sciences Department, University of Life Sciences, ul. Akademicka 13, 20-950 Lublin, Poland.
J Surg Case Rep. 2024 Oct 5;2024(10):rjae612. doi: 10.1093/jscr/rjae612. eCollection 2024 Oct.
Mixed neuroendocrine-nonneuroendocrine epithelial neoplasms are rare malignant neoplasms that may occur in the bladder with highly aggressive behavior. Because of its worse prognosis, when compared to the pure urothelial carcinoma without the neuroendocrine component, the bladder mixed neuroendocrine-nonneuroendocrine epithelial neoplasm may be considered a distinct clinicopathologic entity. We present a case of mixed neuroendocrine-nonneuroendocrine epithelial neoplasm occurring in the urinary bladder of an elderly female with a personal history of chronic kidney disease, drug-resistant urinary tract infections, and neurogenic bladder. Her presenting symptoms included complaints of abdominal pain, urinary urgency, oliguria, dysuria, and occasional hematuria. Recognition of the clinicopathologic features of these rare aggressive neoplasms is important for accurate early diagnosis, necessitating appropriate therapeutic management.
混合性神经内分泌-非神经内分泌上皮性肿瘤是一种罕见的恶性肿瘤，可发生于膀胱，具有高度侵袭性。由于其预后较差，与无神经内分泌成分的单纯尿路上皮癌相比，膀胱混合性神经内分泌-非神经内分泌上皮性肿瘤可被视为一种独特的临床病理实体。我们报告一例发生于老年女性膀胱的混合性神经内分泌-非神经内分泌上皮性肿瘤病例，该患者有慢性肾病、耐药性尿路感染和神经源性膀胱病史。她的主要症状包括腹痛、尿急、少尿、尿痛和偶尔的血尿。认识这些罕见侵袭性肿瘤的临床病理特征对于准确早期诊断很重要，需要进行适当的治疗管理。
