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纳米酶在抗菌应用方面的进展。

Progress in antibacterial applications of nanozymes.

作者信息

Zhao Keyuan, Zhao Ye, Wang Yuwei, Han Bo, Lian Meiling

机构信息

Tianjin Engineering Research Center of Civil Aviation Energy Environment and Green Development, School of Transportation Science and Engineering, Civil Aviation University of China, Tianjin, China.

Tianjin Fire Science and Technology Research Institute of MEM, Tianjin, China.

出版信息

Front Chem. 2024 Sep 23;12:1478273. doi: 10.3389/fchem.2024.1478273. eCollection 2024.

Abstract

Bacterial infections are a growing problem, and antibiotic drugs can be widely used to fight bacterial infections. However, the overuse of antibiotics and the evolution of bacteria have led to the emergence of drug-resistant bacteria, severely reducing the effectiveness of treatment. Therefore, it is very important to develop new effective antibacterial strategies to fight multi-drug resistant bacteria. Nanozyme is a kind of enzyme-like catalytic nanomaterials with unique physical and chemical properties, high stability, structural diversity, adjustable catalytic activity, low cost, easy storage and so on. In addition, nanozymes also have excellent broad-spectrum antibacterial properties and good biocompatibility, showing broad application prospects in the field of antibacterial. In this paper, we reviewed the research progress of antibacterial application of nanozymes. At first, the antibacterial mechanism of nanozymes was summarized, and then the application of nanozymes in antibacterial was introduced. Finally, the challenges of the application of antibacterial nanozymes were discussed, and the development prospect of antibacterial nanozymes was clarified.

摘要

细菌感染是一个日益严重的问题,抗生素药物可广泛用于对抗细菌感染。然而,抗生素的过度使用和细菌的进化导致了耐药菌的出现,严重降低了治疗效果。因此,开发新的有效抗菌策略以对抗多重耐药菌非常重要。纳米酶是一类具有独特物理化学性质、高稳定性、结构多样性、可调节催化活性、低成本、易于储存等特点的类酶催化纳米材料。此外,纳米酶还具有优异的广谱抗菌性能和良好的生物相容性,在抗菌领域显示出广阔的应用前景。本文综述了纳米酶抗菌应用的研究进展。首先总结了纳米酶的抗菌机制,然后介绍了纳米酶在抗菌方面的应用。最后讨论了抗菌纳米酶应用面临的挑战,并阐明了抗菌纳米酶的发展前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4d/11456495/443a0466a6df/fchem-12-1478273-g001.jpg

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