• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

金属-有机骨架调制的 FeO 复合纳米金颗粒通过协同过氧化物酶样纳米酶催化用于抗菌性伤口愈合。

Metal-organic framework-modulated FeO composite au nanoparticles for antibacterial wound healing via synergistic peroxidase-like nanozymatic catalysis.

机构信息

College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, Henan, China.

Key Laboratory of Functional Molecules for Biomedical Research, Henan University of Technology, Zhengzhou, 450001, Henan, China.

出版信息

J Nanobiotechnology. 2023 Nov 15;21(1):427. doi: 10.1186/s12951-023-02186-6.

DOI:10.1186/s12951-023-02186-6
PMID:37968680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10647143/
Abstract

Bacterial wound infections are a serious threat due to the emergence of antibiotic resistance. Herein, we report an innovative hybrid nanozyme independent of antibiotics for antimicrobial wound healing. The hybrid nanozymes are fabricated from ultra-small Au NPs via in-situ growth on metal-organic framework (MOF)-stabilised FeO NPs (FeO@MOF@Au NPs, FMA NPs). The fabricated hybrid nanozymes displayed synergistic peroxidase (POD)-like activities. It showed a remarkable level of hydroxyl radicals (·OH) in the presence of a low dose of HO (0.97 mM). Further, the hybrid FMA nanozymes exhibited excellent biocompatibility and favourable antibacterial effects against both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. The animal experiments indicated that the hybrid nanozymes promoted wound repair with adequate biosafety. Thus, the well-designed hybrid nanozymes represent a potential strategy for healing bacterial wound infections, without any toxic side effects, suggesting possible applications in antimicrobial therapy.

摘要

细菌引起的伤口感染是一个严重的威胁，因为抗生素耐药性的出现。在此，我们报告了一种创新的混合纳米酶，它不依赖抗生素，可用于抗菌伤口愈合。该混合纳米酶是通过在金属有机骨架（MOF）稳定的 FeO NPs（FeO@MOF@Au NPs，FMA NPs）上原位生长超小 Au NPs 制备的。所制备的混合纳米酶表现出协同过氧化物酶（POD）样活性。在低剂量 HO（0.97 mM）存在下，它显示出显著水平的羟基自由基（·OH）。此外，混合 FMA 纳米酶表现出良好的生物相容性和对革兰氏阴性（大肠杆菌）和革兰氏阳性（金黄色葡萄球菌）细菌的良好抗菌作用。动物实验表明，混合纳米酶具有足够的生物安全性，促进了伤口修复。因此，设计良好的混合纳米酶代表了一种治疗细菌感染性伤口的潜在策略，没有任何毒副作用，这表明它们可能在抗菌治疗中有应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/f552fdae0578/12951_2023_2186_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/04c24f30d368/12951_2023_2186_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/5baa6f16dc3f/12951_2023_2186_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/6e36bb769e29/12951_2023_2186_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/4af5f39dea7f/12951_2023_2186_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/348d8774e289/12951_2023_2186_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/d0ee930b5813/12951_2023_2186_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/819e2a6684ba/12951_2023_2186_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/45d772dff2fc/12951_2023_2186_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/b1b69c80a2b5/12951_2023_2186_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/1a40405736d9/12951_2023_2186_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/f552fdae0578/12951_2023_2186_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/04c24f30d368/12951_2023_2186_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/5baa6f16dc3f/12951_2023_2186_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/6e36bb769e29/12951_2023_2186_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/4af5f39dea7f/12951_2023_2186_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/348d8774e289/12951_2023_2186_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/d0ee930b5813/12951_2023_2186_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/819e2a6684ba/12951_2023_2186_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/45d772dff2fc/12951_2023_2186_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/b1b69c80a2b5/12951_2023_2186_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/1a40405736d9/12951_2023_2186_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e5/10647143/f552fdae0578/12951_2023_2186_Fig9_HTML.jpg

相似文献

1
Metal-organic framework-modulated FeO composite au nanoparticles for antibacterial wound healing via synergistic peroxidase-like nanozymatic catalysis.金属-有机骨架调制的 FeO 复合纳米金颗粒通过协同过氧化物酶样纳米酶催化用于抗菌性伤口愈合。
J Nanobiotechnology. 2023 Nov 15;21(1):427. doi: 10.1186/s12951-023-02186-6.
2
In Situ Fabrication of Ultrasmall Gold Nanoparticles/2D MOFs Hybrid as Nanozyme for Antibacterial Therapy.原位合成超小金纳米粒子/二维 MOFs 杂化纳米酶用于抗菌治疗。
Small. 2020 Jun;16(23):e2000553. doi: 10.1002/smll.202000553. Epub 2020 May 5.
3
Peroxidase-like Nanozymes for Point-of-Care SERS Sensing and Wound Healing.用于即时护理表面增强拉曼光谱传感和伤口愈合的过氧化物酶样纳米酶
ACS Appl Bio Mater. 2023 Mar 20;6(3):1272-1282. doi: 10.1021/acsabm.3c00008. Epub 2023 Feb 28.
4
Integrating Artificial DNAzymes with Natural Enzymes on 2D MOF Hybrid Nanozymes for Enhanced Treatment of Bacteria-Infected Wounds.二维 MOF 杂化纳米酶上整合人工 DNA 酶和天然酶用于增强治疗细菌感染伤口
Small. 2024 May;20(21):e2307256. doi: 10.1002/smll.202307256. Epub 2023 Nov 28.
5
Ultrathin trimetallic metal-organic framework nanosheets for accelerating bacteria-infected wound healing.用于加速细菌感染伤口愈合的超薄三金属金属有机骨架纳米片。
J Colloid Interface Sci. 2022 Dec 15;628(Pt B):731-744. doi: 10.1016/j.jcis.2022.08.073. Epub 2022 Aug 17.
6
Construction of a photothermal hydrogel platform with two-dimensional PEG@zirconium-ferrocene MOF nanozymes for rapid tissue repair of bacteria-infected wounds.构建具有二维 PEG@锆基金属有机框架纳米酶的光热水凝胶平台，用于快速修复细菌感染伤口的组织。
Acta Biomater. 2021 Nov;135:342-355. doi: 10.1016/j.actbio.2021.08.022. Epub 2021 Aug 25.
7
Controlled-temperature photothermal and oxidative bacteria killing and acceleration of wound healing by polydopamine-assisted Au-hydroxyapatite nanorods.聚多巴胺辅助金-羟基磷灰石纳米棒的控温热光和氧化细菌杀灭及加速伤口愈合。
Acta Biomater. 2018 Sep 1;77:352-364. doi: 10.1016/j.actbio.2018.07.030. Epub 2018 Jul 17.
8
Metal-Organic Framework Modified MoS Nanozyme for Synergetic Combating Drug-Resistant Bacterial Infections via Photothermal Effect and Photodynamic Modulated Peroxidase-Mimic Activity.金属有机框架修饰的 MoS2 纳米酶通过光热效应和光动力调制过氧化物酶模拟活性协同对抗耐药菌感染。
Adv Healthc Mater. 2022 Jan;11(1):e2101698. doi: 10.1002/adhm.202101698. Epub 2021 Sep 22.
9
pH-responsive double-enzyme active metal-organic framework for promoting the healing of infected wounds.pH 响应型双酶活性金属有机框架促进感染性伤口愈合。
J Colloid Interface Sci. 2024 Mar;657:250-262. doi: 10.1016/j.jcis.2023.11.143. Epub 2023 Nov 27.
10
Quaternized chitosan coated copper sulfide nanozyme with peroxidase-like activity for synergistic antibacteria and promoting infected wound healing.具有过氧化物酶样活性的季铵化壳聚糖包覆硫化铜纳米酶用于协同抗菌和促进感染伤口愈合
Int J Biol Macromol. 2023 Aug 15;246:125651. doi: 10.1016/j.ijbiomac.2023.125651. Epub 2023 Jul 1.

引用本文的文献

1
Recent advances in metal-organic frameworks for antibacterial applications: mechanisms and emerging strategies.用于抗菌应用的金属有机框架的最新进展：作用机制与新兴策略
RSC Adv. 2025 Jul 28;15(33):26710-26727. doi: 10.1039/d5ra02955d. eCollection 2025 Jul 25.
2
Recent Advances in Metal-Organic Framework-Based Nanozymes for Intelligent Microbial Biosensing: A Comprehensive Review of Biomedical and Environmental Applications.基于金属有机框架的纳米酶用于智能微生物生物传感的最新进展：生物医学与环境应用综述
Biosensors (Basel). 2025 Jul 7;15(7):437. doi: 10.3390/bios15070437.
3
Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications.

本文引用的文献

1
Reversing ferroptosis resistance by MOFs through regulation intracellular redox homeostasis.金属有机框架材料通过调节细胞内氧化还原稳态逆转铁死亡抗性
Asian J Pharm Sci. 2023 Jan;18(1):100770. doi: 10.1016/j.ajps.2022.11.004. Epub 2022 Dec 17.
2
Fe-Doped MoS Nanozyme for Antibacterial Activity and Detoxification of Mustard Gas Simulant.用于抗菌活性和芥子气模拟物解毒的铁掺杂二硫化钼纳米酶
ACS Appl Mater Interfaces. 2022 Sep 28;14(38):42940-42949. doi: 10.1021/acsami.2c11245. Epub 2022 Sep 19.
3
A flexible visual detection of calcium peroxide in flour employing enhanced catalytic activity of heterogeneous catalysts binary copper trapped silica-layered magnetite nanozyme.
基于刺激响应性纳米酶的先进伤口愈合：机制、设计与应用
J Nanobiotechnology. 2025 Jul 1;23(1):479. doi: 10.1186/s12951-025-03558-w.
4
Nanozymes Empower Periodontitis Treatment: New Strategies and Clinical Application Prospects.纳米酶助力牙周炎治疗：新策略与临床应用前景
Biomater Res. 2025 May 20;29:0210. doi: 10.34133/bmr.0210. eCollection 2025.
5
Manganese Phthalocyanine-Based Magnetic Core-Shell Composites with Peroxidase Mimetic Activity for Colorimetric Detection of Ascorbic Acid and Glutathione.具有过氧化物酶模拟活性的基于锰酞菁的磁性核壳复合材料用于比色法检测抗坏血酸和谷胱甘肽
Molecules. 2025 Mar 27;30(7):1484. doi: 10.3390/molecules30071484.
6
Multifunctional metal-organic frameworks as promising nanomaterials for antimicrobial strategies.多功能金属有机框架作为用于抗菌策略的有前景的纳米材料。
Burns Trauma. 2025 Jan 24;13:tkaf008. doi: 10.1093/burnst/tkaf008. eCollection 2025.
7
Recent advances in nanomaterials and their mechanisms for infected wounds management.纳米材料及其在感染伤口管理中的作用机制的最新进展。
Mater Today Bio. 2025 Feb 4;31:101553. doi: 10.1016/j.mtbio.2025.101553. eCollection 2025 Apr.
8
Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing.基于多孔硅构建双驱动促血管生成纳米酶用于协同加速烧伤感染创面愈合
Mater Today Bio. 2025 Jan 24;31:101522. doi: 10.1016/j.mtbio.2025.101522. eCollection 2025 Apr.
9
Nanocatalytic medicine enabled next-generation therapeutics for bacterial infections.纳米催化医学助力细菌感染的下一代治疗方法。
Mater Today Bio. 2024 Sep 16;29:101255. doi: 10.1016/j.mtbio.2024.101255. eCollection 2024 Dec.
10
Progress in antibacterial applications of nanozymes.纳米酶在抗菌应用方面的进展。
Front Chem. 2024 Sep 23;12:1478273. doi: 10.3389/fchem.2024.1478273. eCollection 2024.
利用非均相催化剂二元铜捕获二氧化硅层状磁铁矿纳米酶的增强催化活性对面粉中的过氧化钙进行灵活的视觉检测。
Colloids Surf B Biointerfaces. 2022 Nov;219:112823. doi: 10.1016/j.colsurfb.2022.112823. Epub 2022 Sep 7.
4
Antibacterial biomaterials for skin wound dressing.用于皮肤伤口敷料的抗菌生物材料。
Asian J Pharm Sci. 2022 May;17(3):353-384. doi: 10.1016/j.ajps.2022.01.001. Epub 2022 Jan 24.
5
Development of sodium alginate-based antioxidant and antibacterial bioactive films added with IRMOF-3/Carvacrol.基于海藻酸钠的抗氧化和抗菌生物活性薄膜的开发，添加了 IRMOF-3/香芹酚。
Carbohydr Polym. 2022 Sep 15;292:119682. doi: 10.1016/j.carbpol.2022.119682. Epub 2022 Jun 1.
6
A facile and general method for synthesis of antibiotic-free protein-based hydrogel: Wound dressing for the eradication of drug-resistant bacteria and biofilms.一种简便通用的合成无抗生素蛋白质基水凝胶的方法：用于根除耐药细菌和生物膜的伤口敷料。
Bioact Mater. 2022 Mar 29;18:446-458. doi: 10.1016/j.bioactmat.2022.03.033. eCollection 2022 Dec.
7
Preparation of Photocatalytic and Antibacterial MOF Nanozyme Used for Infected Diabetic Wound Healing.用于感染性糖尿病创面愈合的光催化抗菌 MOF 纳米酶的制备。
ACS Appl Mater Interfaces. 2022 Apr 27;14(16):18194-18208. doi: 10.1021/acsami.2c03001. Epub 2022 Apr 12.
8
Triple-synergistic MOF-nanozyme for efficient antibacterial treatment.用于高效抗菌治疗的三元协同金属有机框架纳米酶
Bioact Mater. 2022 Feb 1;17:289-299. doi: 10.1016/j.bioactmat.2022.01.036. eCollection 2022 Nov.
9
Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing.具有温度敏感自适应形状和可控药物释放的葡萄糖和基质金属蛋白酶-9双响应水凝胶可加速糖尿病伤口愈合。
Bioact Mater. 2022 Jan 19;17:1-17. doi: 10.1016/j.bioactmat.2022.01.004. eCollection 2022 Nov.
10
Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS dual nanozyme for bacteria-infected wound healing.基于单宁酸-金属涂层修饰的二硫化钼双纳米酶构建多功能水凝胶用于细菌感染伤口愈合
Bioact Mater. 2021 Jul 26;9:461-474. doi: 10.1016/j.bioactmat.2021.07.023. eCollection 2022 Mar.