Meretsky Christopher R, Polychronis Andreas, Liovas Dimitria, Schiuma Anthony T
Surgery, St. George's University School of Medicine, Great River, USA.
General Surgery, St. George's University School of Medicine, Great River, USA.
Cureus. 2024 Sep 7;16(9):e68872. doi: 10.7759/cureus.68872. eCollection 2024 Sep.
Tissue engineering represents a revolutionary approach in regenerative medicine, offering promising alternatives to traditional reconstructive techniques. This systematic review explores recent advances in tissue engineering, comparing their efficacy, postoperative outcomes, and patient satisfaction to conventional methods. A comprehensive literature search was conducted across PubMed, Cochrane Library, and Google Scholar, covering studies published from 2000 to 2024. Fourteen studies were selected for final analysis based on inclusion criteria focusing on outcomes such as scar quality, postoperative pain, and patient satisfaction. The review demonstrated that tissue engineering techniques consistently provided superior cosmetic outcomes with minimal scarring compared to traditional methods. Patients undergoing tissue-engineered procedures experienced mild-to-moderate postoperative pain with rapid resolution, whereas traditional techniques resulted in moderate to severe pain requiring extended management. Furthermore, patients treated with tissue engineering reported high satisfaction rates due to improved cosmetic and functional outcomes. Despite challenges such as ensuring adequate vascularization, controlling scaffold degradation, and overcoming regulatory and cost barriers, ongoing research and development are essential to fully realize the potential of these innovative therapies. Tissue engineering offers significant advantages over traditional reconstructive techniques and has the potential to profoundly improve patient care in regenerative medicine.
组织工程是再生医学中的一种革命性方法，为传统重建技术提供了有前景的替代方案。本系统评价探讨了组织工程的最新进展，将其疗效、术后结果和患者满意度与传统方法进行比较。在PubMed、Cochrane图书馆和谷歌学术上进行了全面的文献检索，涵盖了2000年至2024年发表的研究。根据纳入标准，最终分析选择了14项研究，重点关注瘢痕质量、术后疼痛和患者满意度等结果。该评价表明，与传统方法相比，组织工程技术始终能提供更好的美容效果，瘢痕形成最小。接受组织工程手术的患者术后经历轻度至中度疼痛，且疼痛迅速缓解，而传统技术导致中度至重度疼痛，需要长期治疗。此外，接受组织工程治疗的患者因美容和功能结果改善而报告了较高的满意度。尽管存在诸如确保充足血管化、控制支架降解以及克服监管和成本障碍等挑战，但持续的研发对于充分实现这些创新疗法的潜力至关重要。组织工程比传统重建技术具有显著优势，并且有潜力在再生医学中深刻改善患者护理。
