用于治疗骨缺损的骨组织工程技术、进展及支架
Bone tissue engineering techniques, advances and scaffolds for treatment of bone defects.
作者信息
Alonzo Matthew, Primo Fabian Alvarez, Kumar Shweta Anil, Mudloff Joel A, Dominguez Erick, Fregoso Gisel, Ortiz Nick, Weiss William M, Joddar Binata
机构信息
Inspired Materials & Stem-Cell Based Tissue Engineering Laboratory (IMSTEL), The University of Texas at El Paso, El Paso, Texas, 79968, USA.
Department of Metallurgical, Materials, and Biomedical Engineering, M201 Engineering, The University of Texas at El Paso, 500 W. University Avenue, El Paso, Texas, 79968, USA.
出版信息
Curr Opin Biomed Eng. 2021 Mar;17. doi: 10.1016/j.cobme.2020.100248. Epub 2020 Nov 1.
Abstract
Bone tissue engineering (BTE) aims to develop strategies to regenerate damaged or diseased bone using a combination of cells, growth factors, and biomaterials. This article highlights recent advances in BTE, with particular emphasis on the role of the biomaterials as scaffolding material to heal bone defects. Studies encompass the utilization of bioceramics, composites, and myriad hydrogels that have been fashioned by injection molding, electrospinning, and 3D bioprinting over recent years, with the aim to provide an insight into the progress of BTE along with a commentary on their scope and possibilities to aid future research. The biocompatibility and structural efficacy of some of these biomaterials are also discussed.
摘要
骨组织工程（BTE）旨在开发利用细胞、生长因子和生物材料的组合来再生受损或患病骨骼的策略。本文重点介绍了骨组织工程的最新进展，特别强调了生物材料作为修复骨缺损的支架材料的作用。近年来的研究涵盖了生物陶瓷、复合材料和多种通过注塑成型、静电纺丝和3D生物打印制成的水凝胶的应用，目的是深入了解骨组织工程的进展，并对其范围和可能性进行评论，以辅助未来的研究。还讨论了其中一些生物材料的生物相容性和结构功效。
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