Moradi Raheleh, Kashanian Maryam, Mokhber Somayeh, Pazouki Abdolreza
Minimally Invasive Surgery Research Center Iran University of Medical Sciences, Tehran, Iran.
Shahid Akbarabadi Clinical Research Development Unit (ShCRDU) Iran University of Medical Sciences (IUMS), Tehran, Iran.
Case Rep Surg. 2024 Sep 30;2024:4707627. doi: 10.1155/2024/4707627. eCollection 2024.
Premature ovarian insufficiency (POI) is associated with decreased ovulation in the precursor stage which leads to ovarian failure in the end stage. Metabolic-bariatric surgery (MBS) can improve women's reproductive status, including the release of sex hormones, ovulation, and fertilization. Here, we report a spontaneous pregnancy following MBS despite potential ovarian insufficiency. A 38-year-old woman with severe obesity underwent three cycles of assisted reproduction that were not successful. Oligomenorrhea ≥ 4 months, laboratory indices, and previous poor ovarian response approved the diagnosis of diminished ovarian reserve and could be considered as the precursor stage of POI. Then a gastric bypass was applied, and a spontaneous pregnancy occurred in the 22 month after surgery, with 45.80% reduction in body mass index. MBS in women with obesity and idiopathic ovarian insufficiency may increase the chance of spontaneous ovulation and successful pregnancy.
卵巢早衰（POI）与前期排卵减少相关，最终会导致卵巢功能衰竭。代谢减重手术（MBS）可以改善女性的生殖状况，包括性激素释放、排卵和受精。在此，我们报告一例尽管存在潜在卵巢早衰但在代谢减重手术后自然受孕的病例。一名38岁重度肥胖女性接受了三个周期的辅助生殖治疗均未成功。月经稀发≥4个月、实验室指标以及既往卵巢反应不良均证实了卵巢储备功能下降的诊断，可认为处于卵巢早衰的前期阶段。随后进行了胃旁路手术，术后22个月自然受孕，体重指数降低了45.80%。肥胖且患有特发性卵巢早衰的女性接受代谢减重手术可能会增加自然排卵和成功受孕的机会。
