Harreiter Jürgen, Schindler Karin, Bancher-Todesca Dagmar, Göbl Christian, Langer Felix, Prager Gerhard, Gessl Alois, Leutner Michael, Ludvik Bernhard, Luger Anton, Kautzky-Willer Alexandra, Krebs Michael
Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine III, Medical University Vienna, Vienna, Austria.
Division of Endocrinology and Metabolism, Department of Medicine III, Medical University Vienna, Vienna, Austria.
J Obes. 2018 Jun 3;2018:4587064. doi: 10.1155/2018/4587064. eCollection 2018.
The prevalence of obesity is growing worldwide, and strategies to overcome this epidemic need to be developed urgently. Bariatric surgery is a very effective treatment option to reduce excess weight and often performed in women of reproductive age. Weight loss influences fertility positively and can resolve hormonal imbalance. So far, guidelines suggest conceiving after losing maximum weight and thus recommend conception at least 12-24 months after surgery. As limited data of these suggestions exist, further evidence is urgently needed as well for weight gain in pregnancy. Oral glucose tolerance tests for the diagnosis of gestational diabetes mellitus (GDM) should not be performed after bariatric procedures due to potential hypoglycaemic adverse events and high variability of glucose levels after glucose load. This challenges the utility of the usual diagnostic criteria for GDM in accurate prediction of complications. Furthermore, recommendations on essential nutrient supplementation in pregnancy and lactation in women after bariatric surgery are scarce. In addition, nutritional deficiencies or daily intake recommendations in pregnant women after bariatric surgery are not well investigated. This review summarizes current evidence, proposes clinical recommendations in pregnant women after bariatric surgery, and highlights areas of lack of evidence and the resulting urgent need for more clinical investigations.
肥胖症在全球范围内的患病率正在上升,迫切需要制定应对这一流行病的策略。减肥手术是减轻超重的一种非常有效的治疗选择,且常在育龄妇女中进行。体重减轻对生育能力有积极影响,并可解决激素失衡问题。到目前为止,指南建议在体重减轻到最大程度后再怀孕,因此建议在手术后至少12至24个月再受孕。由于关于这些建议的数据有限,对于孕期体重增加也迫切需要更多证据。由于减肥手术后可能出现低血糖不良事件以及葡萄糖负荷后血糖水平的高度变异性,因此不应该在减肥手术后进行口服葡萄糖耐量试验来诊断妊娠期糖尿病(GDM)。这对GDM的常规诊断标准在准确预测并发症方面的效用提出了挑战。此外,关于减肥手术后妇女在妊娠和哺乳期补充必需营养素的建议很少。另外,减肥手术后孕妇的营养缺乏情况或每日摄入量建议尚未得到充分研究。本综述总结了当前证据,提出了减肥手术后孕妇的临床建议,并强调了证据不足的领域以及因此产生的对更多临床研究的迫切需求。