Ray S K, Poddar M K
Eur J Pharmacol. 1985 Dec 17;119(3):251-3. doi: 10.1016/0014-2999(85)90305-x.
Acute administration of the anticholinesterase agent carbaryl to rats produced a dose-dependent increase of tremors. The carbaryl-induced tremor was significantly reduced by prior treatment of the rats with either atropine or L-DOPA and was exacerbated by haloperidol. These results suggest the possible involvement of a central cholinergic-dopaminergic interaction in the carbaryl-induced tremor.
给大鼠急性注射抗胆碱酯酶药物西维因会导致震颤剂量依赖性增加。用阿托品或左旋多巴预先处理大鼠可显著减轻西维因诱导的震颤，而氟哌啶醇则会加剧这种震颤。这些结果表明，中枢胆碱能 - 多巴胺能相互作用可能与西维因诱导的震颤有关。
