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The frequency of haematogenously propagated hepatic metastases occurring from intra-ocular melanoma led us to treat 20 patients with adjuvant chemotherapy. 19 patients starting chemotherapy during the month following enucleation and one patient, a year after enucleation. With a median follow-up of 6 years, 17 patients (80%) are disease-free. Three patients developed hepatic metastases at 24, 24 and 30 months respectively. The résults suggest that adjuvant chemotherapy is effective in preventing metastases from intra-ocular melanoma.
眼内黑色素瘤血行转移至肝脏的高发生率促使我们对20例患者进行辅助化疗。19例患者在眼球摘除术后1个月内开始化疗,1例患者在眼球摘除术后1年开始化疗。中位随访6年,17例患者(80%)无疾病进展。3例患者分别在24个月、24个月和30个月时出现肝转移。结果表明辅助化疗对预防眼内黑色素瘤转移有效。