Papachristou D N, Fortner J J
Int Surg. 1983 Apr-Jun;68(2):145-8.
Metastatic melanoma is rarely confined to a single organ. Ten patients presenting with metastasis limited to the liver were treated surgically. Six of them had primary ocular melanomas. Treatment involved hepatic lobectomy in three and catheterization of the hepatic artery for regional chemotherapy in seven. Median survival following resection was 16 months and following catheterization five months. Nearly all long-term survivors were patients who had ocular melanoma. All patients presented with advanced liver involvement causing hepatomegaly. The study suggests that surgical treatment has a place in the management of solitary liver metastasis if there is no extrahepatic spread and diagnosis is not delayed.
转移性黑色素瘤很少局限于单一器官。10例出现局限于肝脏转移的患者接受了手术治疗。其中6例有原发性眼黑色素瘤。3例接受了肝叶切除术，7例接受了肝动脉插管进行区域化疗。切除术后的中位生存期为16个月，插管术后为5个月。几乎所有长期存活者均为患有眼黑色素瘤的患者。所有患者均表现为肝脏受累严重导致肝肿大。该研究表明，如果没有肝外扩散且诊断不延迟，手术治疗在孤立性肝转移的管理中占有一席之地。
