Townson S, Nelson G S, Bianco A E
J Helminthol. 1985 Dec;59(4):337-46. doi: 10.1017/s0022149x00025931.
The model of Onchocerca lienalis microfilariae (mff) injected into CBA and T.O. strains of mice has been used to examine immunity to skin-dwelling microfilariae following exposure to a range of species of helminths. Mice which had received a primary infection with O. cervicalis mff were significantly resistant to challenge with O. lienalis mff (58% reduction relative to challenge controls). Immunization with the uterine contents (eggs and mff) of O. lienalis, O. gutturosa or O. volvulus conferred equivalent levels of protection against challenge with O. lienalis mff (66 to 75%). Similar results were obtained with immunizations in mice that employed either fresh or freeze-killed eggs of O. gutturosa. Significant reductions in the recoveries of O. lienalis mff were also demonstrated following the intraperitoneal implantation of adult male worms of O. gutturosa (30 to 52%), the adults of either sex of Dipetalonema viteae (60%), or after infection with Trichinella spiralis (27 to 81%). Infections with the trematode, Schistosoma mansoni, had a negligible effect on mff recoveries. It is concluded that partial resistance in mice to Onchocerca mff may be stimulated by factors, yet to be determined, that are neither stage nor species-specific.
已使用将盘尾丝虫属牛丝虫微丝蚴（mff）注射到CBA和T.O.品系小鼠体内的模型，来研究在接触一系列蠕虫种类后对皮肤寄生微丝蚴的免疫力。曾初次感染牛颈盘尾丝虫mff的小鼠对牛丝虫mff的攻击具有显著抗性（相对于攻击对照组减少了58%）。用牛丝虫、喉盘尾丝虫或旋盘尾丝虫的子宫内容物（虫卵和mff）进行免疫，可提供同等水平的保护以抵御牛丝虫mff的攻击（66%至75%）。在用新鲜或冻杀的喉盘尾丝虫虫卵对小鼠进行免疫时也获得了类似结果。在腹腔植入喉盘尾丝虫成年雄虫（30%至52%）、链尾唇旋线虫雌雄成虫（60%）或感染旋毛虫后（27%至81%），牛丝虫mff的回收率也显著降低。感染曼氏血吸虫对mff回收率的影响可忽略不计。得出的结论是，小鼠对盘尾丝虫mff的部分抗性可能由一些尚未确定的因素激发，这些因素既非阶段特异性也非物种特异性。
