Bernard Jérémy, Tamouza Ryad, Godin Ophélia, Berk Michael, Andreazza Ana C, Leboyer Marion
INSERM U955 IMRB, Translational Neuropsychiatry laboratory, AP-HP, Hôpital Henri Mondor, DMU IMPACT, Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie (FHU ADAPT), Paris Est Créteil University (UPEC), Fondation FondaMental, ECNP Immuno-NeuroPsychiatry Network, 94010 Créteil, France.
Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.
Brain Behav Immun. 2025 Jan;123:456-465. doi: 10.1016/j.bbi.2024.10.008. Epub 2024 Oct 6.
In last few decades, considerable evidence has emphasized the significant involvement of mitochondria, often referred to as the "powerhouse of the cell," in the pathophysiology of bipolar disorder (BD). Given crucial mitochondrial functions in cellular metabolism and inflammation, both of which are compromised in BD, this perspective review examines the central role of mitochondria in inflammation and metabolism within the context of this disorder. We first describe the significance of mitochondria in metabolism before presenting the dysregulated inflammatory and metabolic processes. Then, we present a synthetic and hypothetical model of the importance of mitochondria in those dysfunctional pathways. The article also reviews different techniques for assessing mitochondrial function and discuss diagnostic and therapeutic implications. This review aims to improve the understanding of the inflammatory and metabolic comorbidities associated with bipolar disorders along with mitochondrial alterations within this context.
在过去几十年中，大量证据强调了线粒体（常被称为“细胞动力室”）在双相情感障碍（BD）病理生理学中的重要作用。鉴于线粒体在细胞代谢和炎症中具有关键功能，而这两者在BD中均受到损害，本观点综述在该疾病背景下探讨了线粒体在炎症和代谢中的核心作用。我们首先描述线粒体在代谢中的重要性，然后介绍失调的炎症和代谢过程。接着，我们提出一个关于线粒体在这些功能失调途径中重要性的综合假设模型。本文还综述了评估线粒体功能的不同技术，并讨论了其诊断和治疗意义。本综述旨在增进对双相情感障碍相关炎症和代谢共病以及在此背景下线粒体改变的理解。
