Aslam Sumayya, Ibe Ifegwu, Zhang Ying, Demianets Roksolana, Tran Truc, Gamayo Ashley, Zhao Xiaohui, Rezk Sherif A
Department of Pathology and Laboratory Medicine, Irvine Medical Center (UCI), University of California, 101 The City Drive, Bldg. 54, Rm 4702, Orange, CA, 92868, USA.
J Hematop. 2024 Dec;17(4):271-274. doi: 10.1007/s12308-024-00605-7. Epub 2024 Oct 9.
Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm arising from follicular dendritic cells (FDC) of lymphoid follicles. While the majority of FDC sarcoma cases arise within lymph nodes, approximately 30% manifest in extranodal sites. Only 4 prior occurrences of intra-parotid FDC sarcomas have been documented. We are reporting a rare case of FDC of the parotid gland in a 65-year-old male with a questionable history of B-cell lymphoma. The patient underwent a right total parotidectomy and bilateral neck dissection. A diagnosis of follicular dendritic cell (FDC) sarcoma was made, with one positive intra-parotid node. The malignant cells expressed the characteristic markers for FDC sarcoma but with positivity of the melanocytic marker PRAME. This is a case of FDC sarcoma with an unusual extranodal localization in the parotid gland. Immunohistochemistry was useful in making a diagnosis although the positivity for the melanocytic marker PRAME was unusual and unreported before.
滤泡性树突状细胞肉瘤是一种罕见的间叶性肿瘤，起源于淋巴滤泡的滤泡性树突状细胞（FDC）。虽然大多数滤泡性树突状细胞肉瘤病例发生在淋巴结内，但约30%出现在结外部位。此前仅有4例腮腺内滤泡性树突状细胞肉瘤的病例被记录。我们报告一例65岁男性腮腺滤泡性树突状细胞肉瘤罕见病例，该患者有可疑的B细胞淋巴瘤病史。患者接受了右侧全腮腺切除术和双侧颈淋巴结清扫术。诊断为滤泡性树突状细胞（FDC）肉瘤，腮腺内有一个阳性淋巴结。恶性细胞表达滤泡性树突状细胞肉瘤的特征性标志物，但黑素细胞标志物PRAME呈阳性。这是一例腮腺内结外定位异常的滤泡性树突状细胞肉瘤病例。免疫组织化学有助于做出诊断，尽管黑素细胞标志物PRAME呈阳性这一情况不常见且此前未被报道。
