Horner Scarlett B, Lulla Roshni, Wu Helen, Shaktivel Shruti, Vaccaro Anthony, Herschel Ellen, Christov-Moore Leonardo, McDaniel Colin, Kaplan Jonas T, Greening Steven G
Department of Psychology, Brain and Cognitive Sciences, University of Manitoba, 190 Dysart Road, Winnipeg, MB, R3T 2N2, Canada.
Department of Psychology, Brain and Creativity Institute, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA, USA.
Cogn Affect Behav Neurosci. 2025 Apr;25(2):329-343. doi: 10.3758/s13415-024-01232-6. Epub 2024 Oct 8.
Previous behavioral research has found that working memory is associated with emotion regulation efficacy. However, there has been mixed evidence as to whether the neural mechanisms between emotion regulation and working memory overlap. The present study tested the prediction that individual differences on the working memory subtest of the Weschler Adult Intelligence Scale (WAIS-IV) could be predicted from the pattern of brain activity produced during emotion regulation in regions typically associated with working memory, such as the dorsal lateral prefrontal cortex (dlPFC). A total of 101 participants completed an emotion regulation fMRI task in which they either viewed or reappraised negative images. Participants also completed working memory test outside the scanner. A whole brain covariate analysis contrasting the reappraise negative and view negative BOLD response found that activity in the right dlPFC positively related to working memory ability. Moreover, a multivoxel pattern analysis approach using tenfold cross-validated support vector regression in regions-of-interest associated with working memory, including bilateral dlPFC, demonstrated that we could predict individual differences in working memory ability from the pattern of activity associated with emotion regulation. These findings support the idea that emotion regulation shares underlying cognitive processes and neural mechanisms with working memory, particularly in the dlPFC.
先前的行为研究发现，工作记忆与情绪调节效能相关。然而，关于情绪调节和工作记忆之间的神经机制是否重叠，证据并不一致。本研究检验了这样一个预测：韦氏成人智力量表（WAIS-IV）工作记忆子测验中的个体差异，可以从与工作记忆相关的区域（如背外侧前额叶皮层，dlPFC）在情绪调节过程中产生的脑活动模式中预测出来。共有101名参与者完成了一项情绪调节功能磁共振成像任务，在该任务中他们要么观看负面图像，要么对其进行重新评估。参与者还在扫描仪外完成了工作记忆测试。一项全脑协变量分析对比了重新评估负面图像和观看负面图像时的血氧水平依赖（BOLD）反应，发现右侧dlPFC的活动与工作记忆能力呈正相关。此外，一种多体素模式分析方法，在包括双侧dlPFC在内的与工作记忆相关的感兴趣区域中使用十折交叉验证支持向量回归，结果表明我们可以从与情绪调节相关的活动模式中预测工作记忆能力的个体差异。这些发现支持了这样一种观点，即情绪调节与工作记忆共享潜在的认知过程和神经机制，尤其是在dlPFC中。
