Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia.
Department of Microbiology, Faculty of Sciences, University of Gezira, Wad-Medani, Sudan.
Cell Mol Biol (Noisy-le-grand). 2024 Oct 8;70(9):106-113. doi: 10.14715/cmb/2024.70.9.15.
Finding novel, efficient antimicrobial drugs is crucial in this age of pressing global health challenges. The medicinal qualities of the leaves of the argel plant (Solanum argel, or S. argel) have been recognized in traditional medicine for quite some time. The medicinal potential of these leaves may be due to the presence of bioactive substances such as alkaloids, flavonoids, and phenolic acids. S. argel leaf antibacterial, phytochemical, and gas chromatography-mass spectrometry (GC-MS) characteristics are the focus of this investigation. To conduct the study, bioactive compounds would be extracted from the leaves and tested against a panel of bacterial pathogens. Then, the compounds would be identified using GC-MS analysis. Mean inhibition zones of 15.30±1.0 mm, 14.67±0.42 mm, 15.0±0.01 mm, and 15.56±0.22 mm for the bacteria E. coli, Staph. aureus, and Sal. typhimurium, respectively, were seen in the antibacterial results at a concentration of 3 µg/disc. Secondary metabolites such as alkaloids, flavonoids, phenolic substances, and tannins were identified using phytochemical investigation. Antimicrobial, antioxidant, and anti-inflammatory are just a few of the many bioactivities associated with these phytochemicals. Argel plant leaves contain bioactive chemicals that show they could be a source of new pharmaceuticals. Argel leaves were analyzed using GC-MS and 37 different chemicals were found. The most abundant compounds were 4H-Pyran-4-one and 2,3-dihydro-3.5-hydroxy, followed by 3-Pentanol, 2,2,4,4-tetramethyl, and 2,2-Dimethyl-3-[3-methyl-5-(phenylthio)-, with areas of 11.80%, 10.6%, and 9.47%, respectively. The analysis was performed within a time range of 5.070 to 34.464 minutes. According to the research, Argel leaf has powerful antioxidant and antibacterial capabilities, making it an excellent substance for medical and food preservation applications.
在这个全球健康挑战紧迫的时代，寻找新型、高效的抗菌药物至关重要。Argel 植物（Solanum argel 或 S. argel）的叶子在传统医学中已经有很长一段时间被认可具有药用价值。这些叶子的药用潜力可能归因于存在生物活性物质，如生物碱、类黄酮和酚酸。本研究的重点是 Argel 叶的抗菌、植物化学和气相色谱-质谱联用 (GC-MS) 特性。为了进行这项研究，将从叶子中提取生物活性化合物，并对一系列细菌病原体进行测试。然后，使用 GC-MS 分析来鉴定化合物。在 3μg/disc 的浓度下，对细菌 E. coli、Staph. aureus 和 Sal. typhimurium 的抑菌圈直径分别为 15.30±1.0mm、14.67±0.42mm、15.0±0.01mm 和 15.56±0.22mm。通过植物化学研究鉴定出生物碱、类黄酮、酚类物质和单宁等次生代谢物。这些植物化学物质具有抗菌、抗氧化和抗炎等多种生物活性。Argel 植物叶子含有生物活性化合物，表明它们可能是新药物的来源。使用 GC-MS 对 Argel 叶片进行分析，发现了 37 种不同的化学物质。含量最丰富的化合物是 4H-吡喃-4-酮和 2,3-二氢-3.5-羟基，其次是 3-戊醇、2,2,4,4-四甲基和 2,2-二甲基-3-[3-甲基-5-（苯基硫代）-，面积分别为 11.80%、10.6%和 9.47%。分析在 5.070 到 34.464 分钟的时间范围内进行。根据研究，Argel 叶具有强大的抗氧化和抗菌能力，使其成为医疗和食品保鲜应用的绝佳物质。
