Exploring emphysematous osteomyelitis as a potential cause of severe unexplained back pain in advanced metastatic cancer patients.

Emphysematous osteomyelitis (EO) a rare and potentially life-threatening condition caused by gas-forming bacteria, can occasionally affect the spine. Timely diagnosis and appropriate intervention are crucial in preventing rapid deterioration. This article aims to provide insights into the clinical presentation and radiographic findings of emphysematous osteomyelitis of the spine in advanced metastatic cancer patients who may present with severe, unexplained back pain. We present 2 cases of emphysematous osteomyelitis in patients with advanced metastatic cancer. The first case was for a 37-year-old female and the second case was for a 66-year-old male. In both instances, the diagnosis was established based on distinctive radiographic findings. In both cases, the infection was caused by an unusual organism. Medical treatment resulted in pain management and an improvement in performance status for both patients. In conclusion, Emphysematous osteomyelitis (EO) is a rare condition that necessitates prompt diagnosis. The preferred imaging modalities for diagnosing EO are Computed Tomography (CT) rather than Magnetic Resonance Imaging (MRI). Therefore, a comprehensive radiological assessment is crucial in suspected cases. Early identification and treatment can significantly reduce morbidity in this vulnerable patient population and may improve prognosis.