Manoleras Annabel V, Sloan Erica K, Chang Aeson
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Front Oncol. 2024 Sep 24;14:1460493. doi: 10.3389/fonc.2024.1460493. eCollection 2024.
The tumor microenvironment influences cancer progression and response to treatments, which ultimately impacts the survival of patients with cancer. The sympathetic nervous system (SNS) is a core component of solid tumors that arise in the body. In addition to influencing cancer progression, a role for the SNS in the effectiveness of cancer treatments is beginning to emerge. This review explores evidence that the SNS impairs chemotherapy efficacy. We review findings of studies that evaluated the impact of neural ablation on chemotherapy outcomes and discuss plausible mechanisms for the impact of neural signaling on chemotherapy efficacy. We then discuss implications for clinical practice, including opportunities to block neural signaling to improve response to chemotherapy.
肿瘤微环境影响癌症进展和对治疗的反应，最终影响癌症患者的生存。交感神经系统（SNS）是体内实体瘤的核心组成部分。除了影响癌症进展外，SNS在癌症治疗效果中的作用也开始显现。本综述探讨了SNS损害化疗疗效的证据。我们回顾了评估神经消融对化疗结果影响的研究结果，并讨论了神经信号传导对化疗疗效影响的可能机制。然后，我们讨论了对临床实践的影响，包括阻断神经信号传导以改善化疗反应的机会。
