Zhang Yamei, Han Hongping, Li Dingai, Fan Yanan, Liu Meng, Ren Huimin, Liu Lu
School of Chemistry and Chemical Engineering, Qinghai Normal University, Xining, China.
Key Laboratory of Medicinal Plant and Animal Resources of Qinghai-Tibetan Plateau in Qinghai Province, Xining, China.
Front Pharmacol. 2024 Jul 9;15:1428037. doi: 10.3389/fphar.2024.1428037. eCollection 2024.
(FRU) belongs to the genus of the Liliaceae family. It is one of the original plants of the Chinese medicinal material "Chuanbeimu" and also a biological resource featured in the Tibetan Plateau of China. The dried bulbs of FRU are used in traditional Chinese medicine. The chemical constituents of FRU that have been isolated and identified include alkaloids, sterols, organic acids and their esters, nucleosides and volatile oils. FRU has antitussive, expectorant, anti-asthmatic, anti-inflammatory, antibacterial, acute lung injury-reducing, antifibrosis, antitumor, and other pharmacological effects. This valuable plant has an extremely high market demand, and over the years, due to over-exploitation, FRU has now been listed as a key species that is endangered and scarcely cultivated in China as a traditional Chinese medicinal herb. However, research on FRU is rare, and its effective components, resource control, and mechanisms of action need further study. This review systematically discusses the herbal characteristics, resource distribution, chemical composition, biosynthesis, pharmacological effects, clinical application, and breeding techniques of FRU, hoping to provide a reference for further research and the use of FRU.
川贝母属于百合科植物。它是中药材“川贝母”的原植物之一，也是中国青藏高原特有的生物资源。川贝母的干燥鳞茎用于传统中药。已分离鉴定出的川贝母化学成分包括生物碱、甾醇、有机酸及其酯类、核苷和挥发油。川贝母具有止咳、祛痰、平喘、抗炎、抗菌、减轻急性肺损伤、抗纤维化、抗肿瘤等药理作用。这种珍贵的植物市场需求极高，多年来，由于过度开采，川贝母现已被列为中国濒危且极少种植的重点中药材品种。然而，对川贝母的研究较少，其有效成分、资源管控及作用机制有待进一步研究。本文综述系统地探讨了川贝母的本草特征、资源分布、化学成分、生物合成、药理作用、临床应用及繁育技术，希望为川贝母的进一步研究与利用提供参考。
