Willam Carsten, Herbst Larissa
Medizinische Klinik 4, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland.
Med Klin Intensivmed Notfmed. 2024 Nov;119(8):634-639. doi: 10.1007/s00063-024-01193-1. Epub 2024 Oct 9.
The ROSE concept, which is the acronym of resuscitation, optimization, stabilization and evacuation, describes the phases of fluid therapy, based on the pathophysiology of septic shock. During the first two phases, aggressive fluid therapy that is guided by clinical and hemodynamic parameters is mandatory. During the stabilization phase, recovery from shock and microcirculatory injury occurs, which enables the depletion of fluid overload in the fourth and final phase. Ultimately, euvolemia needs to be regained, which reverts interstitial edema and organ dysfunction.
ROSE概念是复苏（Resuscitation）、优化（Optimization）、稳定（Stabilization）和后送（Evacuation）的首字母缩写，它基于脓毒性休克的病理生理学描述了液体治疗的各个阶段。在前两个阶段，必须根据临床和血流动力学参数进行积极的液体治疗。在稳定阶段，休克和微循环损伤开始恢复，这使得在第四阶段也是最后阶段能够消除液体超负荷。最终，需要恢复正常血容量，以逆转间质水肿和器官功能障碍。
