Liu Peng, Zhou Shanshui, Dong Haipeng, Li Jiqiang, Xu Zhihan, Lin Shushen, Yang Wenjie, Yan Fuhua, Qin Le
Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, China.
CT Collaboration, Siemens Healthineers, 399 West Haiyang Road, Shanghai, 200126, China.
Jpn J Radiol. 2025 Feb;43(2):309-318. doi: 10.1007/s11604-024-01671-8. Epub 2024 Oct 9.
To investigate the feasibility and accuracy of iodine quantification using PCD-CT in standard-pitch and high-pitch scanning at different scan parameters in a phantom model.
Four inserts with known iodine concentrations (2, 5, 10, and 15 mg/mL) were placed in the removable CT phantom and scanned using high-pitch (3.2) and standard-pitch (0.8) modes on PCD-CT. Two tube voltages (120 and 140 kVp) and four radiation doses (1, 3, 5, and 10 mGy) were alternated. Each scan setting was repeated three times. Mean iodine concentration for each insert across three consecutive slices was recorded. Percentage absolute bias (PAB) was assessed for iodine quantification.
A total of 96 acquisitions were conducted. In small phantom, the average for PAB was 2.96% (range: 1.75% ~ 4.56%) and 1.67% (range: 1.00% ~ 3.42%) for high-pitch and standard-pitch acquisitions, respectively. In large phantom, it was 3.72% (range: 1.75% ~ 5.97%) and 2.94% (range: 1.75% ~ 4.70%). Linear regression analysis revealed that only phantom size significantly influenced (P < 0.001) the accuracy of iodine quantification.
The high-pitch scan mode in PCD-CT can be used to quantify iodine density with similar accuracy compared with standard pitch.
在体模模型中，研究在不同扫描参数下使用光子计数探测器CT（PCD-CT）进行标准螺距和高螺距扫描时碘定量的可行性和准确性。
将四个已知碘浓度（2、5、10和15mg/mL）的插入物放置在可拆卸的CT体模中，并在PCD-CT上使用高螺距（3.2）和标准螺距（0.8）模式进行扫描。交替使用两种管电压（120和140 kVp）和四种辐射剂量（1、3、5和10 mGy）。每个扫描设置重复三次。记录每个插入物在三个连续层面上的平均碘浓度。评估碘定量的绝对偏差百分比（PAB）。
共进行了96次采集。在小体模中，高螺距和标准螺距采集的PAB平均值分别为2.96%（范围：1.75%4.56%）和1.67%（范围：1.00%3.42%）。在大体模中，分别为3.72%（范围：1.75%5.97%）和2.94%（范围：1.75%4.70%）。线性回归分析显示，只有体模大小对碘定量的准确性有显著影响（P<0.001）。
与标准螺距相比，PCD-CT中的高螺距扫描模式可用于以相似的准确性定量碘密度。
