Engineering Research Center of Nano-Geomaterials of Ministry of Education, China University of Geosciences, Wuhan 430074, China; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China; Laboratory of Advanced Mineral Materials, China University of Geosciences, Wuhan 430074, China.
Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China.
Ultrason Sonochem. 2024 Dec;111:107096. doi: 10.1016/j.ultsonch.2024.107096. Epub 2024 Oct 4.
Bacterial infections pose considerable health risks, emphasising the critical need for effective and biocompatible antibacterial drugs. Considerably, we developed an efficient antimicrobial system incorporating the combined potential of high-frequency ultrasound and antimicrobial drugs against bacterial infections. A ZnO-kaolinite (Kaol) composite with antibacterial properties was synthesised by growing ZnO on the Kaol nano-clay surface using the co-precipitation method. High-frequency ultrasound efficiently promotes the release of Zn, which enhances the antibacterial properties. Furthermore, in-depth in vitro antibacterial studies and bacterial live/dead staining experiments validate the exceptionally high antibacterial performance of the composite. Therefore, owing to the synergistic effects of high-frequency ultrasound and antibacterial properties, the as-prepared novel antibacterial composite is a promising potential substitute for conventional antibacterial agents.
细菌感染对健康构成重大威胁，强调了开发有效且生物相容的抗菌药物的紧迫性。在此背景下，我们开发了一种高效的抗菌系统，结合了高频超声和抗菌药物的协同作用，用于治疗细菌感染。本研究采用共沉淀法在高岭石纳米粘土表面生长 ZnO，合成了具有抗菌性能的 ZnO-高岭土（Kaol）复合材料。高频超声能有效促进 Zn 的释放，从而增强了复合材料的抗菌性能。此外，深入的体外抗菌研究和细菌死活染色实验验证了该复合材料具有极高的抗菌性能。因此，由于高频超声和抗菌性能的协同作用，所制备的新型抗菌复合材料有望成为传统抗菌剂的替代品。
