Xu Jiahui, Liu Yi, Zhang Guangzheng, Wu Jinmei, Cui Xujie, Wei Wenqing, Yuan Ziyan, Bu Linlin, Han Heyou, Li Weihui, Song Zhiyong
National Key Laboratory of Agricultural Microbiology, College of Chemistry, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
National Key Laboratory of Agricultural Microbiology, College of Chemistry, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Ultrason Sonochem. 2025 Aug 25;121:107530. doi: 10.1016/j.ultsonch.2025.107530.
The rapid spread of drug-resistant bacterial infections has become a major global health challenge, particularly in the treatment of deep organ abscesses, which often lead to severe and life-threatening infections. Traditional light-responsive and microenvironment-responsive nanoparticle drug delivery systems (DDSs) have limitations in treating deep abscesses. In contrast, ultrasound (US)-driven sonodynamic therapy (SDT), with its non-invasive, targeted radiation and excellent tissue penetration capabilities, offers great potential for eradicating deep bacterial infections. This study proposes an ultrasound-driven manganese-based nanoparticle drug delivery system (AMP) for the effective treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The core of the system is manganese oxide (MnOx) nanoflowers, which serve as the nanoparticle carrier, loaded with the antimicrobial non-antibiotic drug auranofin, and surface-modified with polyethylene glycol to enhance its biocompatibility and drug delivery performance. AMP demonstrates significant antibacterial activity in vitro and effectively promotes wound healing under US-driven stimulation. Furthermore, the potential antibacterial and wound-healing mechanisms of AMP are revealed for the first time. This study cleverly combines non-antibiotic drugs with inorganic nanomaterials to successfully achieve efficient SDT, providing a new and effective strategy for treating deep bacterial infections.
耐药细菌感染的迅速传播已成为一项重大的全球健康挑战，尤其是在深部器官脓肿的治疗方面，这类脓肿常常会引发严重且危及生命的感染。传统的光响应和微环境响应纳米颗粒药物递送系统（DDSs）在治疗深部脓肿方面存在局限性。相比之下，超声（US）驱动的声动力疗法（SDT）具有非侵入性、靶向辐射和出色的组织穿透能力，在根除深部细菌感染方面具有巨大潜力。本研究提出了一种超声驱动的基于锰的纳米颗粒药物递送系统（AMP），用于有效治疗耐甲氧西林金黄色葡萄球菌（MRSA）感染。该系统的核心是氧化锰（MnOx）纳米花，其作为纳米颗粒载体，负载抗菌非抗生素药物金诺芬，并经聚乙二醇进行表面修饰以增强其生物相容性和药物递送性能。AMP在体外表现出显著的抗菌活性，并在超声驱动刺激下有效促进伤口愈合。此外，首次揭示了AMP潜在的抗菌和伤口愈合机制。本研究巧妙地将非抗生素药物与无机纳米材料相结合，成功实现了高效的声动力疗法，为治疗深部细菌感染提供了一种新的有效策略。
