Huang Danqing, Wang Jinglin, Song Chuanhui, Zhao Yuanjin
Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210002, China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Innovation (Camb). 2023 Apr 6;4(3):100421. doi: 10.1016/j.xinn.2023.100421. eCollection 2023 May 15.
Ultrasound (US) is a biofavorable mechanical wave that has shown practical significance in biomedical fields. Due to the cavitation effect, sonoluminescence, sonoporation, pyrolysis, and other biophysical and chemical effects, a wide range of matters have been elucidated to be responsive to the stimulus of US. This review addresses and discusses current developments in US-responsive matters, including US-breakable intermolecular conjugations, US-catalytic sonosensitizers, fluorocarbon compounds, microbubbles, and US-propelled micro- and nanorobots. Meanwhile, the interactions between US and advanced matters create various biochemical products and enhanced mechanical effects, leading to the exploration of potential biomedical applications, from US-facilitated biosensing and diagnostic imaging to US-induced therapeutic applications and clinical translations. Finally, the current challenges are summarized and future perspectives on US-responsive matters in biomedical applications and clinical translations are proposed.
超声（US）是一种对生物有利的机械波，在生物医学领域已显示出实际意义。由于空化效应、声致发光、声孔效应、热解及其他生物物理和化学效应，已阐明多种物质对超声刺激有响应。本综述阐述并讨论了超声响应性物质的当前进展，包括超声可断裂的分子间共轭物、超声催化声敏剂、碳氟化合物、微泡以及超声驱动的微型和纳米机器人。同时，超声与先进物质之间的相互作用产生了各种生化产物并增强了机械效应，从而推动了潜在生物医学应用的探索，从超声辅助生物传感和诊断成像到超声诱导的治疗应用及临床转化。最后，总结了当前面临的挑战，并对超声响应性物质在生物医学应用和临床转化方面的未来前景提出了建议。
