Adekunle Olajide A, Wang Yun S, Yunusa Ismaeel, Fleming Marc L, Seoane-Vazquez Enrique, Brown Lawrence M
J Am Pharm Assoc (2003). 2025 Jan-Feb;65(1):102255. doi: 10.1016/j.japh.2024.102255. Epub 2024 Oct 9.
Metabolic syndrome (MetS) continues to impact the health-related quality of life (HRQoL) of patients despite various available therapeutic interventions. There is a dearth of information on how patient-centered factors holistically predict HRQoL to provide more insights on addressing MetS.
To predict the HRQoL of patients with MetS in the Southern states, using the predisposing, enabling, and need factors.
The study adopted a cross-sectional approach in collecting 706 complete surveys on HRQoL assessment using the EQ-5D-5L survey and demographic characteristics based on the predisposing, enabling, and need factors of Andersen's Behavioral model. The study focused on people with MetS in the southern states of the United States. Multinomial logistic regression was conducted to investigate the relationship between the number of comorbidities and each HRQoL dimension. Ordinal regression was used to explore factors predicting HRQoL. Sensitivity analysis was conducted using bootstrapping analysis to evaluate the regression's robustness.
Over 70% were females and 30% had at least a bachelor's degree, while 47% were married. Most respondents (71.1%) had no problem with self-care. However, 20.0% had severe problems with pain, while the highest proportion (8.6%) was observed for extreme problems with anxiety or depression. A unit increase in comorbidities resulted in higher odds of having extreme problems with mobility (odds ratio [OR] = 1.95), usual activities (OR = 1.73), and pain (OR = 1.70). Only 40.8% of the respondents had good HRQoL, compared to 26.2% with poor HRQoL. Age, race, geographical area, marital status, household income, number of prescription drugs, comorbidities, and body mass index were predictors of HRQoL.
An increase in comorbidities significantly increased the odds of having challenges with the HRQoL dimensions. Demographic, socioeconomic, and health-related factors significantly predicted HRQoL. Therefore, health care providers must consider these factors as a component of patient-centered care to address health disparities and promote optimal health outcomes among people with MetS.
尽管有各种可用的治疗干预措施，但代谢综合征（MetS）仍继续影响患者的健康相关生活质量（HRQoL）。关于以患者为中心的因素如何全面预测HRQoL以提供更多关于应对MetS的见解，目前缺乏相关信息。
使用易患因素、促成因素和需求因素预测美国南部各州MetS患者的HRQoL。
本研究采用横断面方法，使用EQ-5D-5L调查问卷收集了706份关于HRQoL评估的完整调查问卷以及基于安德森行为模型的易患因素、促成因素和需求因素的人口统计学特征。该研究聚焦于美国南部各州的MetS患者。进行多项逻辑回归以研究合并症数量与每个HRQoL维度之间的关系。使用有序回归来探索预测HRQoL的因素。使用自抽样分析进行敏感性分析以评估回归的稳健性。
超过70%为女性，30%至少拥有学士学位，47%已婚。大多数受访者（71.1%）在自我护理方面没有问题。然而，20.0%的人在疼痛方面存在严重问题，而焦虑或抑郁方面极端问题的比例最高（8.6%）。合并症每增加一个单位，导致行动能力出现极端问题（优势比[OR]=1.95）、日常活动（OR=1.73）和疼痛（OR=1.70）的几率更高。只有40.8%的受访者具有良好的HRQoL，相比之下，HRQoL较差的受访者占26.2%。年龄、种族、地理区域、婚姻状况、家庭收入、处方药数量、合并症和体重指数是HRQoL的预测因素。
合并症的增加显著增加了在HRQoL维度上出现挑战的几率。人口统计学、社会经济和健康相关因素显著预测了HRQoL。因此，医疗保健提供者必须将这些因素视为以患者为中心的护理的一部分，以解决健康差异并促进MetS患者的最佳健康结果。
