Sjöberg P, Bondesson U, Sedin G, Gustafsson J
Eur J Clin Invest. 1985 Dec;15(6):430-6. doi: 10.1111/j.1365-2362.1985.tb00297.x.
The dispositions of the plasticizer di-(2-ethylhexyl) phthalate (DEHP) and its primary metabolite mono-(2-ethylhexyl) phthalate (MEHP) were studied in newborn infants subjected to exchange transfusions. During a single exchange transfusion the amounts of DEHP and MEHP infused ranged from 0.8-3.3 and 0.05-0.20 mg kg-1 body weight, respectively. There were indications that about 30% of the infused DEHP originated from parts of the transfusion set other than the blood bag. Approximately 30% of the infused amount of DEHP was withdrawn during the course of each transfusion. Immediately after the transfusions the plasma levels of DEHP ranged between 5.8 and 19.6 micrograms ml-1, and subsequently they declined rapidly. This decline, probably reflecting distribution of DEHP within the body, was followed by a slower elimination phase. The half-life of this phase was approximately 10 h. The maximal plasma levels of MEHP were about 5 micrograms ml-1. In one pre-term infant the elimination of MEHP was slower than its formation, whereas in one full-term newborn the formation appeared to be rate-limiting for the elimination.
对接受换血治疗的新生儿中增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP）及其主要代谢物邻苯二甲酸单（2-乙基己基）酯（MEHP）的处置情况进行了研究。在单次换血治疗期间，输注的DEHP和MEHP量分别为0.8 - 3.3毫克/千克体重和0.05 - 0.20毫克/千克体重。有迹象表明，输注的DEHP中约30%源自输血装置中血袋以外的部分。每次输血过程中约30%的输注DEHP被清除。输血后即刻，DEHP的血浆水平在5.8至19.6微克/毫升之间，随后迅速下降。这种下降可能反映了DEHP在体内的分布情况，随后是一个较慢的消除阶段。该阶段的半衰期约为10小时。MEHP的最大血浆水平约为5微克/毫升。在一名早产儿中，MEHP的消除速度比其形成速度慢，而在一名足月儿中，形成似乎是消除的限速因素。
