L'Oréal Research and Innovation, Aulnay-sous-Bois, France.
Department of Data Analytics, O-SMOSE, Bordeaux, France.
Sci Rep. 2024 Oct 9;14(1):23643. doi: 10.1038/s41598-024-65083-4.
Apparent skin age can be determined by several clinical measurements and may differ from chronological age, hence defining age acceleration/deceleration (Age A/D). Using data from 360 women with dermatological scoring of 21 clinical signs, we defined 3 well-separated co-occurring classes capturing the dryness, the elasticity and the oily nature of the skin. We related the risk of each clinical signs to the stratum corneum levels of 5 pre-selected proteins, we identified specific chronological age-adjusted signatures of each clinical sign. Using variable selection approaches, we identified 6 (of the 21) clinical signs which were jointly predictive of chronological age and used to define the clinical skin age, and subsequently age A/D. Applying univariate and multivariate approaches we found that stratum corneum levels of insulin degrading enzyme (IDE) was protective against (β = - 1.74, p = 3.3 × 10; selection proportion > 90%) accelerated skin ageing. In conclusion, our results support the fact that molecular markers found in the stratum corneum could predict skin ageing acceleration/deceleration.
表观皮肤年龄可通过几种临床测量来确定，并且可能与实际年龄不同，因此可以定义年龄加速/减速（Age A/D）。我们使用来自 360 名女性的皮肤学评分 21 个临床体征的数据，定义了 3 个分离良好的同时存在的类别，这些类别分别反映了皮肤的干燥、弹性和油性。我们将每种临床体征的风险与 5 种预先选定的蛋白质的角质层水平相关联，我们确定了每种临床体征的特定与实际年龄相适应的特征。使用变量选择方法，我们确定了 6 个（21 个中的）临床体征可以共同预测实际年龄，并用于定义临床皮肤年龄，随后是年龄 A/D。应用单变量和多变量方法，我们发现胰岛素降解酶（IDE）的角质层水平对加速皮肤老化具有保护作用（β=-1.74，p=3.3×10；选择比例>90%）。总之，我们的结果支持这样一个事实，即角质层中发现的分子标志物可以预测皮肤老化的加速/减速。
