Denda M, Koyama J, Hori J, Horii I, Takahashi M, Hara M, Tagami H
Shiseido Research Center, Yokohama, Japan.
Arch Dermatol Res. 1993;285(7):415-7. doi: 10.1007/BF00372135.
We measured six stratum corneum sphingolipid species (ceramides 1-6) in 26 males and 27 females, and found a significant change in their percentage composition only among female subjects of different age groups. There was a significant increase in ceramide 1 and 2 with a corresponding decrease in ceramide 3 and 6 from prepubertal age to adulthood. Thereafter the ratio of ceramide 2 to total sphingolipids decreased with age in contrast to ceramide 3 which showed an increase. Such a pattern of change in the aging population is different from that observed in scaly skin experimentally induced by tape stripping. The present results suggest a significant influence of female hormones on the composition of stratum corneum sphingolipids. Moreover, the different patterns of change in sphingolipid composition of stratum corneum lipids between scales from inflammatory skin and those from aged skin also suggest that epidermal biosynthesis of sphingolipids is influenced by epidermal proliferative activity.
我们测量了26名男性和27名女性的六种角质层鞘脂种类（神经酰胺1 - 6），发现只有不同年龄组的女性受试者其百分比组成有显著变化。从青春期前到成年期，神经酰胺1和2显著增加，同时神经酰胺3和6相应减少。此后，与显示增加的神经酰胺3相反，神经酰胺2与总鞘脂的比例随年龄下降。这种老年人群的变化模式不同于胶带剥离实验诱导的鳞状皮肤中观察到的模式。目前的结果表明女性激素对角质层鞘脂组成有显著影响。此外，炎症性皮肤鳞屑和老年皮肤鳞屑之间角质层脂质鞘脂组成的不同变化模式也表明鞘脂的表皮生物合成受表皮增殖活性影响。
