Huang Xiaowen, Cai Jian, Xiao Jiao, Zhou Xuefeng, Liu Yonghong, Li Yunqiu, Yang Bin
Guilin Medical University, Guilin, Guangxi, China.
South China Sea Institute of Oceanography, Chinese Academy of Sciences, Key Laboratory of Tropical Marine Biological Resources and Ecology, Chinese Academy of Sciences, Guangzhou, Guangdong, China.
Chem Biodivers. 2025 Feb;22(2):e202402152. doi: 10.1002/cbdv.202402152. Epub 2024 Nov 14.
A pair of unidentified atropo-diastereomeric dimers, penicisteckins G (1) and H (2), and twelve known compounds (3-16) were isolated from the marine coral-derived fungus Penicillium steckii SCISO 41228. Their structures including the absolute configuration were determined by HR-ESI-MS, ECD, 1D-, and 2D-NMR spectra. Compounds 1 and 2 exhibited moderate antibacterial activity against most tested pathogenic strains, especially for methicillin-resistant Staphyloccocus aureus (MASA) and Micrococcus luteus, with MIC values of 4.0 μg mL. In addition, compounds 2 and 3 exhibit potent radical scavenging activity against 2,2-diphenyl-1-picrylhydrazylhydrate (DPPH), with IC values of 10.76 and 8.66 μg mL, respectively.
从海洋珊瑚来源的真菌青霉SCISO 41228中分离出一对未鉴定的阻转非对映二聚体，青霉司他汀G（1）和H（2），以及12种已知化合物（3 - 16）。通过高分辨电喷雾电离质谱（HR-ESI-MS）、电子圆二色谱（ECD）、一维和二维核磁共振谱（1D-、2D-NMR）确定了它们的结构，包括绝对构型。化合物1和2对大多数测试病原菌表现出中等抗菌活性，尤其是对耐甲氧西林金黄色葡萄球菌（MASA）和藤黄微球菌，最小抑菌浓度（MIC）值为4.0 μg/mL。此外，化合物2和3对2,2-二苯基-1-苦基肼水合物（DPPH）表现出较强的自由基清除活性，IC值分别为10.76和8.66 μg/mL。
