Li Yong, Li Xifeng, Lee Uk, Kang Jung Sook, Choi Hong Dae, Sona Byeng Wha
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Chem Pharm Bull (Tokyo). 2006 Jun;54(6):882-3. doi: 10.1248/cpb.54.882.
A new anthracene glycoside, asperflavin ribofuranoside (1), and the previously described polyketides, flavoglaucin (2), isodihydroauroglaucin (3), and citrinin (4) have been isolated from the marine-derived fungus Microsporum sp. The structure and absolute stereochemistry of a new compound (1) was assigned on the basis of physicochemical data. Compounds 1-3 exhibited a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC(50) values of 14.2, 11.3, and 11.5 microM, respectively, which are more potent than the positive control, ascorbic acid (IC(50), 20 microM). Compound 1 also showed a moderate antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC value of 50 microg/ml.
从海洋来源的真菌小孢子菌属中分离出一种新的蒽糖苷，曲霉黄素核糖呋喃糖苷（1），以及先前描述的聚酮化合物，黄青霉素（2）、异二氢金霉素（3）和桔霉素（4）。根据物理化学数据确定了新化合物（1）的结构和绝对立体化学。化合物1-3对1,1-二苯基-2-苦基肼（DPPH）表现出显著的自由基清除活性，IC50值分别为14.2、11.3和11.5微摩尔，比阳性对照抗坏血酸（IC50，20微摩尔）更有效。化合物1对耐甲氧西林和多重耐药金黄色葡萄球菌（MRSA和MDRSA）也表现出中等抗菌活性，MIC值为50微克/毫升。
