Morad Moataz, Alzahrani Seraj O, Almahri Albandary, Alatawi Ibrahim S S, Alrashdi Kamelah S, Alkhamis Kholood M, Alsharief Hatun H, El-Metwaly Nashwa M
Department of Chemistry, Faculty of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Department of Chemistry, College of Science, Taibah University, P. O. Box 344, Madinah, Saudi Arabia.
BMC Chem. 2024 Oct 9;18(1):194. doi: 10.1186/s13065-024-01290-4.
Povidone-iodine is identified as one of the widely applicable antiseptic reagents for treatment of skin infection and wound healing. Controllable releasing of povidone-iodine is extensively required for healing of chronic wounds. The release of povidone-iodine was systematically studied from the composites based on carboxymethyl starch (CMS). Currently, different ratios from copper precursor and L-aspartic acid (L-AA) were interacted with CMS to obtain Cu-L-AA@CMS composites. Increment the percentage of L-AA was reflected in clustering of dense masses from the desirable composite with highly crystalline/stable structural network. Regardless to pH conditions, Cu-L-AA(30%)@CMS composite showed the highest efficiency for controllable release of povidone-iodine, whereas, the release percentages were estimated to be 58%, 32% and 18% at pH 5, 7 and 9, respectively. The kinetic results revealed the impossibility of povidone-iodine releasing via diffusion/erosion for further support of the hypothesis of releasing via swelling process. Moreover, the release of povidone-iodine using column technique showed that the lowest release was estimated at using high rate of 6 mL/min. Besides the biocompatibility and biodegradability of the prepared Cu-L-AA@CMS composites, it showed the superiority for controllable release of povidone-iodine antiseptic reagent to regulate its beneficial effect in curing of the skin.
聚维酮碘被认为是治疗皮肤感染和伤口愈合广泛适用的抗菌剂之一。慢性伤口愈合广泛需要聚维酮碘的可控释放。基于羧甲基淀粉（CMS）的复合材料对聚维酮碘的释放进行了系统研究。目前，铜前体和L-天冬氨酸（L-AA）以不同比例与CMS相互作用，以获得Cu-L-AA@CMS复合材料。L-AA百分比的增加反映在具有高度结晶/稳定结构网络的理想复合材料中致密团块的聚集上。无论pH条件如何，Cu-L-AA(30%)@CMS复合材料对聚维酮碘的可控释放效率最高，而在pH 5、7和9时，释放百分比分别估计为58%、32%和18%。动力学结果表明，聚维酮碘不可能通过扩散/侵蚀释放，从而进一步支持了通过溶胀过程释放的假设。此外，使用柱技术对聚维酮碘的释放表明，在6 mL/min的高速率下释放最低。除了制备的Cu-L-AA@CMS复合材料具有生物相容性和生物降解性外，它在可控释放聚维酮碘抗菌剂以调节其在皮肤治疗中的有益作用方面表现出优越性。
