Department of Epidemiology and Biostatistics, Hangzhou Normal University, Hangzhou, China.
Department of Health Management, Hangzhou Normal University, Hangzhou, China.
Int J Public Health. 2024 Sep 25;69:1607640. doi: 10.3389/ijph.2024.1607640. eCollection 2024.
We aim to investigate the associations between lifestyle, ambient air pollution with crucial outcomes in the progression of adult asthma, including asthma new-onset and asthma hospitalisation.
176,800 participants were included to assess the prospective association between baseline risk exposures and the subsequent asthma onset, 17,387 participants were used to evaluate asthma hospitalisation. Cox regression models were employed to examine the associations.
In terms of lifestyle factors, the HRs (95% CIs) of the least healthy lifestyle categories for asthma incidence and hospitalization were 1.099 (1.017-1.187) and 1.064 (1.008-1.123), respectively. For pollutants, PM, especially the traffic-related PM component, was consistently recognized as a significant risk factor for asthma onset (HR = 1.064, 95% CI: 1.034-1.094) and hospitalisation (HR = 1.031, 95% CI: 1.010-1.052) under various model adjustments. Low socioeconomic status also played a major role in the progression of adult asthma.
Our study provides crucial insights into factors influencing the progression of adult asthma. Monitoring and reducing exposure to air pollution, particularly PM, promoting healthier lifestyle, and addressing socioeconomic inequity are important in preventing and managing asthma.
我们旨在研究生活方式和环境空气污染与成人哮喘进展的关键结果之间的关联，包括哮喘新发和哮喘住院。
纳入 176800 名参与者评估基线风险暴露与随后哮喘发病之间的前瞻性关联，纳入 17387 名参与者评估哮喘住院。采用 Cox 回归模型来检验相关性。
就生活方式因素而言，最不健康生活方式类别的哮喘发病率和住院率的 HR（95%CI）分别为 1.099（1.017-1.187）和 1.064（1.008-1.123）。对于污染物，PM，尤其是与交通相关的 PM 成分，被一致认为是哮喘发病（HR=1.064，95%CI：1.034-1.094）和住院（HR=1.031，95%CI：1.010-1.052）的重要危险因素，在各种模型调整下。社会经济地位低也在成人哮喘的进展中起主要作用。
本研究提供了影响成人哮喘进展的因素的重要见解。监测和减少空气污染暴露，特别是 PM，促进更健康的生活方式，以及解决社会经济不平等，是预防和管理哮喘的重要措施。
