Furtado Thiago Pardini, Osadchiy Vadim, Furtado Marcelo Horta
Department of Urology David Geffen School of Medicine, UCLA, Los Angeles, USA.
Andrology Department, MF Fertilidade Masculina, Belo Horizonte, Brazil.
Andrology. 2024 Oct 10. doi: 10.1111/andr.13759.
Infertility affects a significant percentage of couples worldwide, with male infertility contributing substantially in a considerable number of cases. Research indicates that oxidative stress is a critical factor impacting male fertility.
To explore the relationship between semen static oxidation-reduction potential (sORP), sperm parameters, and validated biomarkers of oxidative stress in infertile men.
This cross-sectional study involved 202 men diagnosed with idiopathic male factor infertility and male partners from couples with unexplained infertility. Multivariable linear regression to query the associations between sORP, sperm parameters, and oxidative aggression biomarkers (lipid peroxidation, mitochondrial membrane potential, annexin V, and sperm DNA fragmentation).
SORP has no linear association with any semen analysis parameter. Furthermore, its relationship with validated biomarkers of oxidative stress was inconsistent. sORP was inversely related to lipid peroxidation (multivariable linear regression coefficient: -0.64), positively associated with sperm DNA fragmentation (multivariable linear regression coefficient: 3.20), and unrelated to mitochondrial membrane potential or annexin V.
There is no clear or consistent relationship between sORP and validated oxidative aggression biomarkers or sperm parameters. Our findings suggest that sORP is unlikely to be helpful in the evaluation of a male with idiopathic infertility.
不孕影响着全球相当比例的夫妇，在相当多的病例中男性不育占很大比例。研究表明，氧化应激是影响男性生育能力的关键因素。
探讨不育男性精液静态氧化还原电位（sORP）、精子参数与氧化应激验证生物标志物之间的关系。
这项横断面研究纳入了202名被诊断为特发性男性因素不育的男性以及不明原因不育夫妇的男性伴侣。采用多变量线性回归来探究sORP、精子参数与氧化损伤生物标志物（脂质过氧化、线粒体膜电位、膜联蛋白V和精子DNA碎片）之间的关联。
sORP与任何精液分析参数均无线性关联。此外，其与氧化应激验证生物标志物的关系并不一致。sORP与脂质过氧化呈负相关（多变量线性回归系数：-0.64），与精子DNA碎片呈正相关（多变量线性回归系数：3.20），与线粒体膜电位或膜联蛋白V无关。
sORP与验证的氧化损伤生物标志物或精子参数之间没有明确或一致的关系。我们的研究结果表明，sORP不太可能有助于评估特发性不育男性。
