Aznar J A, Carbonell F, Jorquera J I, Carmona E, Sánchez-Cuenca J M, Trénor A, de Andrés-Medina R, González-Molina A
Ric Clin Lab. 1985 Oct-Dec;15(4):315-21. doi: 10.1007/BF03029145.
Peripheral blood lymphocyte populations and subpopulations of 154 hemophiliacs treated with factor VIII concentrates were studied. The patients had significantly increased percentages of leukocytes and lymphocytes and also absolute numbers of the lymphocyte populations in cells/mm3. The increases in cell counts in the two major T cell subpopulations (T4 and T8) were unbalanced, leading to a significant decrease in the T4/T8 ratio. There was no correlation between the T4/T8 ratio and the consumption of factor VIII during the year prior to the study. The values of these T cell subpopulations and of the T4/T8 ratio significantly correlated with the patient's age. There were no analytical or clinical data for any of the patients indicating AIDS.
对154例接受凝血因子VIII浓缩物治疗的血友病患者的外周血淋巴细胞群体和亚群进行了研究。患者的白细胞和淋巴细胞百分比显著增加，细胞/mm³中的淋巴细胞群体绝对数量也增加。两个主要T细胞亚群（T4和T8）的细胞计数增加不均衡，导致T4/T8比值显著降低。在研究前一年，T4/T8比值与凝血因子VIII的消耗量之间没有相关性。这些T细胞亚群的值和T4/T8比值与患者年龄显著相关。没有任何患者的分析或临床数据表明患有艾滋病。
