Musakka Emma-Reetta, Ylilauri Maija Paula Tuulia, Jalanka Jonna, Karvonen Anne Maarit, Täubel Martin, Hantunen Sari, Lehto Soili Marianne, Pekkanen Juha, Backman Katri, Keski-Nisula Leea, Kirjavainen Pirkka Viljami
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Department of Public Health, Finnish Institute for Health and Welfare, Kuopio, Finland.
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Department of Public Health, Finnish Institute for Health and Welfare, Kuopio, Finland.
Med. 2025 Feb 14;6(2):100514. doi: 10.1016/j.medj.2024.09.003. Epub 2024 Oct 9.
The means of primary prevention of asthma are limited. Maternal physical activity during pregnancy promotes fetal lung development and the newborn's lung function; thus, it could lower asthma risk and aid in asthma prevention. The objective of this study is to determine whether maternal physical activity during pregnancy is associated with asthma development in the child.
The study population included 963 mother-infant pairs from the prospective Kuopio Birth Cohort study. Data on maternal physical activity during pregnancy, confounding factors, and children's asthma at 5 to 7 years of age were obtained from the Kuopio University Hospital birth registry and questionnaires.
Maternal physical activity during pregnancy, when practiced three or more times per week, was associated with a reduced risk of asthma in the child, with an adjusted odds ratio of 0.54 (95% confidence interval 0.33-0.89; p = 0.02). The association was stable across a comprehensive set of adjustments, including length of gestation, mode of delivery, and maternal health indicators (e.g., asthma, smoking, pre-pregnancy body mass index and weight gain during pregnancy, infections, medication, healthy diet, stress), as well as various family environment variables.
Maternal physical activity during pregnancy may be associated with marked protection of asthma in childhood and should be studied further as an applicable measure for asthma prevention.
The study has been financially supported by grants from the Academy of Finland (no. 349427), the Emil Aaltonen Foundation, the Finnish Cultural Foundation, the Yrjö Jahnsson Foundation, the Juho Vainio Foundation (no. 202200461), the Kuopio Area Respiratory Foundation, and the Ida Montini Foundation.
哮喘的一级预防手段有限。孕期母亲进行体育活动可促进胎儿肺部发育和新生儿肺功能；因此，这可能降低哮喘风险并有助于预防哮喘。本研究的目的是确定孕期母亲体育活动是否与儿童哮喘的发生有关。
研究人群包括来自前瞻性库奥皮奥出生队列研究的963对母婴。孕期母亲体育活动、混杂因素以及儿童5至7岁时哮喘的数据来自库奥皮奥大学医院出生登记处和问卷调查。
孕期母亲每周进行三次或更多次体育活动与儿童哮喘风险降低相关，调整后的优势比为0.54（95%置信区间0.33 - 0.89；p = 0.02）。在一系列全面的调整中，该关联是稳定的，这些调整包括妊娠期长度、分娩方式以及母亲健康指标（如哮喘、吸烟、孕前体重指数和孕期体重增加、感染、用药、健康饮食、压力），以及各种家庭环境变量。
孕期母亲体育活动可能与显著预防儿童哮喘有关，应作为一种适用的哮喘预防措施进一步研究。
本研究得到了芬兰科学院（编号349427）、埃米尔·阿尔托宁基金会、芬兰文化基金会、伊尔约·亚恩松基金会、尤霍·瓦伊尼奥基金会（编号202200461）、库奥皮奥地区呼吸基金会和艾达·蒙蒂尼基金会的资助。
