Jouve R, Larrue J
Arch Mal Coeur Vaiss. 1985 Dec;78 Spec No:49-55.
An activation of the arachidonic acid cascade has long been reported in coronary artery diseases. However, no clear-cut connection has been demonstrated between this activation and the clinical manifestations of myocardial ischemia. Controlled trials with the available cyclooxygenase inhibitory drugs support the view that these agents might be useful in subgroups of patients. However, these are not known. The peculiar pharmacologic properties of prostacyclin and PGE1 have been documented to improve experimental and clinical acute myocardial ischemia. Further efforts are needed to elucidate the usefulness of some PGs in the management of patients with ischemic heart disease and their contributory role to the disease.
长期以来，已有报道称在冠状动脉疾病中花生四烯酸级联反应被激活。然而，这种激活与心肌缺血的临床表现之间尚未证实有明确的联系。使用现有环氧化酶抑制药物的对照试验支持了这些药物可能对某些亚组患者有用的观点。然而，这些亚组并不明确。前列环素和前列腺素E1独特的药理特性已被证明可改善实验性和临床急性心肌缺血。需要进一步努力阐明某些前列腺素在缺血性心脏病患者管理中的作用及其对该疾病的促成作用。
