Malt R A, Kingsnorth A N, Lamuraglia G M, Lacaine F, Ross J S
Adv Enzyme Regul. 1985;24:93-102. doi: 10.1016/0065-2571(85)90071-8.
Specific, irreversible, inhibition of ODC activity with DFMO and resultant low levels of intracellular polyamines markedly suppress the induction of experimental colonic and mammary cancers and hold promise for augmenting the multidrug chemotherapy of established colonic, pancreatic, renal and mammary cancers without increasing systemic toxicity.
用二氟甲基鸟氨酸（DFMO）特异性、不可逆地抑制鸟氨酸脱羧酶（ODC）活性以及由此导致的细胞内多胺水平降低，可显著抑制实验性结肠癌和乳腺癌的诱发，并有望在不增加全身毒性的情况下，增强对已确诊的结肠癌、胰腺癌、肾癌和乳腺癌的多药化疗效果。
