Sadrzadeh Sayyed Majid, Shahri Bahram, Kamandi Mostafa, Adimolmasali Maryam, Rezvani Kakhki Behrang, Feiz Disfani Hamideh
Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Bull Emerg Trauma. 2024;12(3):130-135. doi: 10.30476/beat.2024.103126.1520.
Recently, different serum markers have been used for the diagnosis and prognosis of acute heart diseases in emergency departments. To determine such a role, the present study was designed and conducted.
This is an analytical cross-sectional study conducted on patients with syncope complaints. The patients enrolled in the study based on the inclusion and exclusion criteria and underwent initial evaluations, including collecting a history, physical examination, ECG, blood sugar measurement, and, if necessary, brain CT scan, Doppler echocardiography, and CTA.
This study included 100 participants who complained of syncope. The results showed that 19% and 81% of the subjects suffered from cardiac and non-cardiac syncope, respectively. The average Pro BNP of the studied individuals was 196.06±128.45 pg/mL. According to the results, age and length of hospitalization had a positive and significant relationship with the average Pro BNP (<0.01). Individuals with positive TPI, cardiac syncope, and abnormal ECG or Doppler findings had significantly higher average Pro BNP levels (<0.01). The results of the diagnostic value of Pro BNP in diagnosing cardiac syncope also showed that its sensitivity and specificity were 94.73% and 56.79%, respectively.
The results of this study showed that the increase in the Pro BNP values was associated with age, length of hospitalization, and ECG abnormalities. In addition, as an independent marker, Pro BNP had optimal acceptability in identifying cardiac syncope cases.
最近，不同的血清标志物已被用于急诊科急性心脏病的诊断和预后评估。为确定其作用，开展了本研究。
这是一项针对有晕厥主诉患者的分析性横断面研究。根据纳入和排除标准招募患者，并进行初步评估，包括采集病史、体格检查、心电图、血糖测量，必要时进行脑部CT扫描、多普勒超声心动图和CT血管造影。
本研究纳入了100名有晕厥主诉的参与者。结果显示，分别有19%和81%的受试者患有心源性晕厥和非心源性晕厥。研究对象的平均脑钠肽前体为196.06±128.45 pg/mL。结果表明，年龄和住院时间与平均脑钠肽前体呈正相关且具有显著意义（<0.01）。TPI阳性、有心源性晕厥以及心电图或多普勒检查结果异常的个体，其平均脑钠肽前体水平显著更高（<0.01）。脑钠肽前体在诊断心源性晕厥中的诊断价值结果还显示，其敏感性和特异性分别为94.73%和56.79%。
本研究结果表明，脑钠肽前体值的升高与年龄、住院时间和心电图异常有关。此外，作为一个独立标志物，脑钠肽前体在识别心源性晕厥病例方面具有最佳的可接受性。
