Liu Yu, Liu Chunxiuzi, Tang Shaohua, Xiao Hui, Wu Xinlin, Peng Yunru, Wang Xianyi, Que Linjie, Di Zengru, Zhou Da, Heinemann Matthias
Department of Systems Science, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, China.
International Academic Center of Complex Systems, Beijing Normal University, Zhuhai, China.
iScience. 2024 Sep 18;27(10):110981. doi: 10.1016/j.isci.2024.110981. eCollection 2024 Oct 18.
The interplay between cellular mechanics and biochemical processes in the cell cycle is not well understood. We propose a quantitative model of cell budding in as a "weaken-fill-repair" process, linking Newtonian mechanics of the cell wall with biochemical changes that affect its properties. Our model reveals that (1) oscillations in mother cell size during budding are an inevitable outcome of the process; (2) asymmetric division is necessary for the daughter cell to maintain mechanical stiffness; and (3) although various aspects of the cell are constrained and interconnected, the budding process is governed by a single reduced parameter, ψ, which balances osmolyte accumulation with enzymatic wall-weakening to ensure homeostasis. This model provides insights into the evolution of cell walls and their role in cell division, offering a system-level perspective on cell morphology.
细胞周期中细胞力学与生化过程之间的相互作用尚未得到充分理解。我们提出了一个酵母细胞出芽的定量模型，将其作为一个“弱化-填充-修复”过程，把细胞壁的牛顿力学与影响其特性的生化变化联系起来。我们的模型揭示：（1）出芽过程中母细胞大小的振荡是该过程不可避免的结果；（2）不对称分裂对于子细胞维持机械刚度是必要的；（3）尽管细胞的各个方面受到约束且相互关联，但出芽过程由单个简化参数ψ控制，该参数平衡渗透溶质积累与酶促细胞壁弱化以确保体内平衡。该模型为细胞壁的进化及其在细胞分裂中的作用提供了见解，从系统层面给出了细胞形态的观点。
