Barakat Muna, Thiab Samar, Abdulrazzaq Shaymaa B, Al-Jamal Marah, AlHariri Fotoh, Bassam Ammari Rakan, Mansour Sara, El Khatib Sami, Hallit Souheil, Hosseini Basile, Malaeb Diana, Hosseini Hassan
Department of Clinical Pharmacy and Therapeutics, School of Pharmacy, Applied Science Private University, Amman, Jordan.
Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan.
J Pharm Policy Pract. 2024 Oct 9;17(1):2410199. doi: 10.1080/20523211.2024.2410199. eCollection 2024.
This study aimed to assess medication adherence among Jordanian patients with dyslipidemia and evaluate the impact of health literacy, well-being, and doctor-patient communication on adherence in this population. Dyslipidemia is a prevalent condition that significantly increases the risk of cardiovascular diseases, and understanding the factors influencing medication adherence is crucial for improving patient outcomes.
An observational cross-sectional study was conducted from March to July 2023. A convenience sample of adult Jordanians diagnosed with dyslipidemia was surveyed in a tertiary hospital using validated scales: the Lebanese Medication Adherence Scale-14 (LMAS-14), the Doctor-Patient Communication Scale (DPC), the WHO well-being index, and the health literacy scale. Bivariate analysis and linear regression models were employed to analyze associations.
Among 410 participants (mean age 58.62 ± 12.11 years), the mean scores were LMAS-14 (35.10), DPC (55.77), WHO well-being (47.53), and health literacy (38.96). Higher medication adherence was associated with older age ( = 0.093, = 0.049), university education ( = 2.872, = 0.017), prior surgery ( = 2.317, = 0.021), medium income level ( = 3.605, = 0.006), and better doctor-patient communication ( = 0.166, = 0.003). Conversely, cigarette smoking ( = -3.854, = 0.001) and health insurance ( = -2.146, = 0.039) were linked to lower adherence.
The findings underscore the substantial interplay of socio-demographic and clinical factors affecting medication adherence. Enhanced public health interventions focusing on improving health literacy, communication quality, and addressing socio-economic conditions are vital for better adherence and patient outcomes in Jordan.
本研究旨在评估约旦血脂异常患者的药物依从性，并评估健康素养、幸福感和医患沟通对该人群依从性的影响。血脂异常是一种普遍存在的疾病，会显著增加心血管疾病的风险，了解影响药物依从性的因素对于改善患者预后至关重要。
2023年3月至7月进行了一项观察性横断面研究。在一家三级医院，使用经过验证的量表对确诊为血脂异常的成年约旦人便利样本进行了调查：黎巴嫩药物依从性量表-14（LMAS-14）、医患沟通量表（DPC）、世界卫生组织幸福感指数和健康素养量表。采用双变量分析和线性回归模型分析相关性。
在410名参与者（平均年龄58.62±12.11岁）中，平均得分分别为LMAS-14（35.10）、DPC（55.77）、世界卫生组织幸福感（47.53）和健康素养（38.96）。较高的药物依从性与年龄较大（β = 0.093，P = 0.049）、大学教育（β = 2.872，P = 0.017）、既往手术史（β = 2.317，P = 0.021）、中等收入水平（β = 3.605，P = 0.006）以及较好的医患沟通（β = 0.166，P = 0.003）相关。相反，吸烟（β = -3.854，P = 0.001）和健康保险（β = -2.146，P = 0.039）与较低的依从性相关。
研究结果强调了影响药物依从性的社会人口学和临床因素之间的重要相互作用。在约旦，加强侧重于提高健康素养、沟通质量和解决社会经济状况的公共卫生干预措施对于提高依从性和改善患者预后至关重要。
