Department of Critical Care Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Department of Surgery ICU, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Front Cell Infect Microbiol. 2024 Sep 26;14:1357178. doi: 10.3389/fcimb.2024.1357178. eCollection 2024.
Sepsis, a disease with high incidence, mortality, and treatment costs, has a complex interaction with the gut microbiota. With advances in high-throughput sequencing technology, the relationship between sepsis and intestinal dysbiosis has become a new research focus. However, owing to the intricate interplay between critical illness and clinical interventions, it is challenging to establish a causal relationship between sepsis and intestinal microbiota imbalance. In this review, the correlation between intestinal microecology and sepsis was summarized, and new therapies for sepsis intervention based on microecological target therapy were proposed, and the shortcomings of bacterial selection and application timing in clinical practice were addressed. In conclusion, current studies on metabolomics, genomics and other aspects aimed at continuously discovering potential probiotics are all providing theoretical basis for restoring intestinal flora homeostasis for subsequent treatment of sepsis.
脓毒症是一种发病率、死亡率和治疗费用都很高的疾病，它与肠道微生物群之间存在着复杂的相互作用。随着高通量测序技术的进步，脓毒症与肠道菌群失调的关系已成为新的研究热点。然而，由于危重病和临床干预之间的复杂相互作用，很难确定脓毒症和肠道微生物失衡之间存在因果关系。本综述总结了肠道微生态与脓毒症的相关性，提出了基于微生态靶向治疗的脓毒症干预新疗法，并探讨了临床实践中细菌选择和应用时机的不足。总之，目前针对代谢组学、基因组学等方面的研究，旨在不断发现潜在的益生菌，为恢复肠道菌群平衡提供了理论依据，为后续脓毒症的治疗提供了理论依据。
