Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.
Shambhunath Institute of Pharmacy, Prayagraj, Uttar Pradesh, India.
J Biochem Mol Toxicol. 2024 Nov;38(11):e70003. doi: 10.1002/jbt.70003.
Citrus fruits are extensively cultivated and eaten both raw and in refined forms. Citrus fruit peels are highly concentrated in polyphenolic substances. This makes them useful resources. Polymethoxyflavones (PMFs), found in citrus peels, belong to a specific subclass of flavonoids where most or all hydroxyl groups are methylated. PMFs have been documented to possess chemopreventive actions, anticancer, anti-inflammatory, and anti-atherosclerosis properties, as well as neuroprotective effects. Sudachitin, a PMF, is primarily found in Citrus sudachi. Japan's Tokushima prefecture is home to this famous fruit. In recent years, there has been a growing interest among researchers in exploring the potential health benefits of sudachitin, spurred by its presence in traditional diets and its association with various positive health outcomes. Studies conducted over the past decade have revealed promising effects of sudachitin in multiple health conditions, including cancer, skin disorders, inflammatory conditions, diabetes, obesity, and neurodegenerative disorders. Although these promising results exist, there is still a need for thorough preclinical and clinical research to confirm sudachitin's effectiveness in treating chronic conditions. This review seeks to summarize animal and cell studies exploring sudachitin's pharmacological properties and the potential molecular pathways underlying its therapeutic effects. Through this, we aim to clarify the clinical potential of sudachitin across various disorders, paving the way for future research and the development of sudachitin-based therapies.
柑橘类水果广泛种植和食用，无论是生的还是精制的。柑橘类水果果皮富含多酚类物质。这使它们成为有用的资源。多甲氧基黄酮（PMFs）存在于柑橘果皮中，属于黄酮类化合物的一个特定亚类，其中大多数或所有羟基都被甲基化。PMFs 已被证明具有化学预防作用、抗癌、抗炎和抗动脉粥样硬化特性以及神经保护作用。柚皮素是一种 PMF，主要存在于日本柚子中。日本的德岛县是这种著名水果的产地。近年来，由于其存在于传统饮食中以及与各种健康积极结果相关，研究人员对探索柚皮素潜在健康益处的兴趣日益浓厚。过去十年的研究表明，柚皮素有多种健康状况的潜在效果，包括癌症、皮肤疾病、炎症、糖尿病、肥胖和神经退行性疾病。尽管这些有希望的结果存在，但仍需要进行彻底的临床前和临床研究，以确认柚皮素在治疗慢性疾病方面的有效性。本综述旨在总结探讨柚皮素药理学特性及其治疗作用潜在分子途径的动物和细胞研究。通过这样做，我们旨在阐明柚皮素在各种疾病中的临床潜力，为未来的研究和基于柚皮素的治疗方法的发展铺平道路。
