Yuasa Keizo, Tada Kaori, Harita Genki, Fujimoto Tomomi, Tsukayama Masao, Tsuji Akihiko
Department of Biological Science and Technology, The University of Tokushima Graduate School, Tokushima, Japan.
Biosci Biotechnol Biochem. 2012;76(3):598-600. doi: 10.1271/bbb.110800.
Although some polymethoxyflavones possess several important biological properties, including neuroprotective, anticancer, and anti-inflammatory ones, sudachitin, a polymethoxyflavone from Citrus sudachi, has been little studied. In this study, we found that sudachitin inhibited nitric oxide production by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide-stimulated macrophages, indicating that sudachitin has an anti-inflammatory effect.
尽管一些多甲氧基黄酮具有多种重要的生物学特性，包括神经保护、抗癌和抗炎特性，但来自酸橘的多甲氧基黄酮类化合物——酸橘苷，却鲜有研究。在本研究中，我们发现酸橘苷通过抑制脂多糖刺激的巨噬细胞中诱导型一氧化氮合酶的表达来抑制一氧化氮的产生，这表明酸橘苷具有抗炎作用。
