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本文引用的文献

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Hand Surgery Patient Perspectives on Medical Cannabis: A Survey of Over 600 Patients.手部手术患者对医用大麻的看法:一项对600多名患者的调查
J Hand Surg Glob Online. 2022 Apr 22;5(1):102-107. doi: 10.1016/j.jhsg.2022.02.009. eCollection 2023 Jan.
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Use of Cannabis Does Not Decrease Opioid Consumption in Patients Who Underwent Total Joint Arthroplasty.大麻的使用并不会减少接受全关节置换术患者的阿片类药物消费量。
Arthroplast Today. 2022 May 10;15:141-146. doi: 10.1016/j.artd.2022.03.018. eCollection 2022 Jun.
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Trends over time in adult cannabis use: A review of recent findings.成人使用大麻的时间趋势:近期研究结果综述。
Curr Opin Psychol. 2021 Apr;38:80-85. doi: 10.1016/j.copsyc.2021.03.005. Epub 2021 Mar 20.
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Cannabinoids and orthopedic surgery: a systematic review of therapeutic studies.大麻素与骨科手术:治疗研究的系统综述。
J Orthop Surg Res. 2021 Jan 14;16(1):57. doi: 10.1186/s13018-021-02205-y.
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Cannabinoid and Opioid Use Among Total Joint Arthroplasty Patients: A 6-Year, Single-Institution Study.全膝关节置换术后患者使用大麻素和阿片类药物:一项为期 6 年的单机构研究。
Orthopedics. 2021 Jan 1;44(1):e101-e106. doi: 10.3928/01477447-20200928-02. Epub 2020 Oct 1.
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Effects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human laboratory study.口服、吸食和蒸发大麻对与食欲和代谢相关的内分泌途径的影响:一项随机、双盲、安慰剂对照、人体实验室研究。
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Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development.更正:培养的血液免疫细胞中糖皮质激素激活后的差异转录反应:创伤后应激障碍生物标志物开发的新方法。
Transl Psychiatry. 2020 Jan 6;10(1):1. doi: 10.1038/s41398-019-0665-5.
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Characteristics of Marijuana Use Among Orthopedic Patients.骨科患者使用大麻的特征。
Orthopedics. 2020 Mar 1;43(2):108-112. doi: 10.3928/01477447-20191212-07. Epub 2019 Dec 16.
9
Frequency of cannabis and illicit opioid use among people who use drugs and report chronic pain: A longitudinal analysis.药物使用者中报告慢性疼痛的人与同时使用大麻和非法阿片类药物的频率:一项纵向分析。
PLoS Med. 2019 Nov 19;16(11):e1002967. doi: 10.1371/journal.pmed.1002967. eCollection 2019 Nov.
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Epilepsy and Cannabis: A Literature Review.癫痫与大麻:文献综述
Cureus. 2018 Sep 10;10(9):e3278. doi: 10.7759/cureus.3278.

大麻素在手疾病疼痛管理中的患病率及作用

Prevalence and Effect of Cannabinoids in Pain Management for Hand Pathologies.

作者信息

Sleiman Marc G, Straszewski Andrew, Stepan Jeffrey G, Conti Mica Megan

机构信息

The University of Chicago, IL, USA.

The University of Chicago Medicine, IL, USA.

出版信息

Hand (N Y). 2024 Oct 11:15589447241284275. doi: 10.1177/15589447241284275.

DOI:10.1177/15589447241284275
PMID:39392237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11559846/
Abstract

BACKGROUND

Cannabinoids are a diverse group of compounds under investigation for various medical purposes, including analgesia. Given the evolving landscape of cannabinoid use, we aimed to analyze their prevalence and effect in pain management among urban orthopedic hand patients.

METHODS

An electronic survey was administered to 122 new patients presenting to the orthopedic hand clinic of a major urban academic hospital. Demographic data, numerical rating scale pain scores, cannabinoid usage, and other concomitant pain regimens were recorded.

RESULTS

Approximately half of the new patients were dissatisfied with current pain management for their hand pathology. Prescription (Rx) and over-the-counter (OTC) pain medications were used by 58% (71/122) of patients, while cannabinoids were used by 15% (18/122) of patients. Compared with pre-usage pain scores, both cannabinoids and Rx/OTC medications induced significant reductions in pain associated with patients' hand pathologies (Cannabinoid: Δ4.4, = .002; Rx/OTC: Δ3.0, < .001). Cannabinoids induced a larger analgesic effect, but this difference was not statistically or clinically significant ( = .06). Subjectively, cannabinoid users either preferred their cannabinoid over Rx/OTC medications or liked both equally. Opioid use was higher among cannabinoid users (22.2% vs 12.5%), although this was not statistically significant ( = .28).

CONCLUSION

Approximately 15% of new urban hand patients use cannabinoids for pain control, and these compounds have similar analgesic efficacy in hand pathologies as Rx/OTC medications. Cannabinoids are equally liked or preferred relative to traditional medications in this cohort, and they may play an important role in pain management for hand patients.

摘要

背景

大麻素是一类多样的化合物,正被研究用于包括镇痛在内的各种医学目的。鉴于大麻素使用情况不断变化,我们旨在分析其在城市骨科手部患者疼痛管理中的流行情况及效果。

方法

对一家大型城市学术医院骨科手部诊所的122名新患者进行了电子调查。记录了人口统计学数据、数字评分量表疼痛评分、大麻素使用情况及其他伴随的疼痛治疗方案。

结果

约一半的新患者对当前手部疾病的疼痛管理不满意。58%(71/122)的患者使用了处方(Rx)和非处方(OTC)止痛药,而15%(18/122)的患者使用了大麻素。与使用前的疼痛评分相比,大麻素和Rx/OTC药物均使与患者手部疾病相关的疼痛显著减轻(大麻素:Δ4.4,P = .002;Rx/OTC:Δ3.0,P < .001)。大麻素诱导的镇痛效果更大,但这种差异在统计学或临床上均无显著意义(P = .06)。主观上,使用大麻素的患者要么更喜欢大麻素而非Rx/OTC药物,要么对两者同样喜欢。大麻素使用者中阿片类药物的使用率更高(22.2%对12.5%),尽管这在统计学上无显著意义(P = .28)。

结论

约15%的城市手部新患者使用大麻素控制疼痛,这些化合物在手部疾病中的镇痛效果与Rx/OTC药物相似。在这一队列中,大麻素与传统药物同样受喜爱或更受青睐,它们可能在手部患者的疼痛管理中发挥重要作用。