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大麻素在手疾病疼痛管理中的患病率及作用

Prevalence and Effect of Cannabinoids in Pain Management for Hand Pathologies.

作者信息

Sleiman Marc G, Straszewski Andrew, Stepan Jeffrey G, Conti Mica Megan

机构信息

The University of Chicago, IL, USA.

The University of Chicago Medicine, IL, USA.

出版信息

Hand (N Y). 2024 Oct 11:15589447241284275. doi: 10.1177/15589447241284275.

Abstract

BACKGROUND

Cannabinoids are a diverse group of compounds under investigation for various medical purposes, including analgesia. Given the evolving landscape of cannabinoid use, we aimed to analyze their prevalence and effect in pain management among urban orthopedic hand patients.

METHODS

An electronic survey was administered to 122 new patients presenting to the orthopedic hand clinic of a major urban academic hospital. Demographic data, numerical rating scale pain scores, cannabinoid usage, and other concomitant pain regimens were recorded.

RESULTS

Approximately half of the new patients were dissatisfied with current pain management for their hand pathology. Prescription (Rx) and over-the-counter (OTC) pain medications were used by 58% (71/122) of patients, while cannabinoids were used by 15% (18/122) of patients. Compared with pre-usage pain scores, both cannabinoids and Rx/OTC medications induced significant reductions in pain associated with patients' hand pathologies (Cannabinoid: Δ4.4, = .002; Rx/OTC: Δ3.0, < .001). Cannabinoids induced a larger analgesic effect, but this difference was not statistically or clinically significant ( = .06). Subjectively, cannabinoid users either preferred their cannabinoid over Rx/OTC medications or liked both equally. Opioid use was higher among cannabinoid users (22.2% vs 12.5%), although this was not statistically significant ( = .28).

CONCLUSION

Approximately 15% of new urban hand patients use cannabinoids for pain control, and these compounds have similar analgesic efficacy in hand pathologies as Rx/OTC medications. Cannabinoids are equally liked or preferred relative to traditional medications in this cohort, and they may play an important role in pain management for hand patients.

摘要

背景

大麻素是一类多样的化合物,正被研究用于包括镇痛在内的各种医学目的。鉴于大麻素使用情况不断变化,我们旨在分析其在城市骨科手部患者疼痛管理中的流行情况及效果。

方法

对一家大型城市学术医院骨科手部诊所的122名新患者进行了电子调查。记录了人口统计学数据、数字评分量表疼痛评分、大麻素使用情况及其他伴随的疼痛治疗方案。

结果

约一半的新患者对当前手部疾病的疼痛管理不满意。58%(71/122)的患者使用了处方(Rx)和非处方(OTC)止痛药,而15%(18/122)的患者使用了大麻素。与使用前的疼痛评分相比,大麻素和Rx/OTC药物均使与患者手部疾病相关的疼痛显著减轻(大麻素:Δ4.4,P = .002;Rx/OTC:Δ3.0,P < .001)。大麻素诱导的镇痛效果更大,但这种差异在统计学或临床上均无显著意义(P = .06)。主观上,使用大麻素的患者要么更喜欢大麻素而非Rx/OTC药物,要么对两者同样喜欢。大麻素使用者中阿片类药物的使用率更高(22.2%对12.5%),尽管这在统计学上无显著意义(P = .28)。

结论

约15%的城市手部新患者使用大麻素控制疼痛,这些化合物在手部疾病中的镇痛效果与Rx/OTC药物相似。在这一队列中,大麻素与传统药物同样受喜爱或更受青睐,它们可能在手部患者的疼痛管理中发挥重要作用。

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